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anti-NR0B2 antibody :: NR0B2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127945
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR0B2, Polyclonal Antibody

★Popular Item★
 Also Known As   

NR0B2 Polyclonal Antibody

 Product Synonym Names    SHP; SHP1
 Product Gene Name   

anti-NR0B2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 604630
 3D Structure    ModBase 3D Structure for Q15466
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Source    Rabbit
 Immunogen    Recombinant protein of human NR0B2
 Calculated Molecular Weight    28kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-NR0B2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NR0B2 antibody

   The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
 Product Categories/Family for anti-NR0B2 antibody    Polyclonal
 Applications Tested/Suitable for anti-NR0B2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NR0B2 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:10 - 1:100
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 Western Blot (WB) of anti-NR0B2 antibody    Western blot analysis of extracts of various cell lines, using NR0B2 antibody.
anti-NR0B2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-NR0B2 antibody    Immunohistochemistry of paraffin-embedded rat lung using NR0B2 antibody at dilution of 1:100 (400x lens).
anti-NR0B2 antibody Immunohistochemistry (IHC (IHC) image
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 Immunofluorescence (IF) of anti-NR0B2 antibody    Immunofluorescence analysis of U2OS cell using NR0B2 antibody. Blue: DAPI for nuclear staining.
anti-NR0B2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for NR0B2. It may not necessarily be applicable to this product.
 NCBI GI #    9978744
 NCBI GeneID    8431
 NCBI Accession #    Q15466.2 [Other Products]
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 UniProt Primary Accession #    Q15466 [Other Products]
 UniProt Secondary Accession #    Q5QP36; F1D8P5 [Other Products]
 UniProt Related Accession #    Q15466 [Other Products]
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 NCBI Official Full Name    Nuclear receptor subfamily 0 group B member 2
 NCBI Official Synonym Full Names    nuclear receptor subfamily 0, group B, member 2
 NCBI Official Symbol    NR0B2 [Similar Products]
 NCBI Official Synonym Symbols   
SHP; SHP1
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 0 group B member 2; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP
 UniProt Protein Name    Nuclear receptor subfamily 0 group B member 2
 UniProt Synonym Protein Names   
Orphan nuclear receptor SHP; Small heterodimer partner
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR0B2 [Similar Products]
 UniProt Synonym Gene Names    SHP [Similar Products]
 UniProt Entry Name    NR0B2_HUMAN
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 NCBI Summary for NR0B2    The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NR0B2    NR0B2: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. Defects in NR0B2 may be associated with obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the nuclear hormone receptor family. NR0 subfamily.

Protein type: Nuclear receptor co-regulator; Nuclear receptor; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleus

Molecular Function: retinoid X receptor binding; protein domain specific binding; protein binding; peroxisome proliferator activated receptor binding; protein homodimerization activity; DNA binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor binding; transcription factor activity; transcription corepressor activity

Biological Process: cholesterol metabolic process; transcription initiation from RNA polymerase II promoter; organ regeneration; negative regulation of transcription factor activity; response to glucose stimulus; positive regulation of insulin secretion; steroid hormone mediated signaling; gene expression; negative regulation of transcription from RNA polymerase II promoter

Disease: Obesity
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 Research Articles on NR0B2    1. E2F1 transcription factor activates early growth response (Egr)-1 promoter which is repressed by SHP and EIA-like inhibitor of differentiation (EID)1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR0B2 antibodyPathways associated with anti-NR0B2 antibody
 Reference Product  PubMed Publications
 NR5A2 antibody  >7 publications with NR0B2 and NR5A2
 PPARG antibody  >2 publications with NR0B2 and PPARG
 HNF4A antibody  >2 publications with NR0B2 and HNF4A
 ESRRG antibody  >2 publications with NR0B2 and ESRRG
 NR4A1 antibody  >1 publications with NR0B2 and NR4A1
 ESR1 antibody  >1 publications with NR0B2 and ESR1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
Diseases associated with anti-NR0B2 antibodyOrgans/Tissues associated with anti-NR0B2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >16 publications with NR0B2 and Liver Diseases
 Obesity Antibodies  >14 publications with NR0B2 and Obesity
 Liver Neoplasms Antibodies  >11 publications with NR0B2 and Liver Neoplasms
 Fatty Liver Antibodies  >7 publications with NR0B2 and Fatty Liver
 Disease Models, Animal Antibodies  >6 publications with NR0B2 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with NR0B2 and Carcinoma, Hepatocellular
 Cholestasis Antibodies  >3 publications with NR0B2 and Cholestasis
 Fibrosis Antibodies  >3 publications with NR0B2 and Fibrosis
 Inflammation Antibodies  >2 publications with NR0B2 and Inflammation
 Liver Neoplasms, Experimental Antibodies  >2 publications with NR0B2 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >35 publications with NR0B2 and Liver
 Kidney Antibodies  >3 publications with NR0B2 and Kidney
 Heart Antibodies  >3 publications with NR0B2 and Heart
 Lung Antibodies  >1 publications with NR0B2 and Lung
 Intestine Antibodies  >1 publications with NR0B2 and Intestine
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