NP_001123573.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 50 kDa Predicted: 51 kDa
NCBI Official Full Name
oxysterols receptor LXR-alpha isoform 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 1 group H member 3
NCBI Protein Information
oxysterols receptor LXR-alpha
UniProt Protein Name
Oxysterols receptor LXR-alpha
UniProt Synonym Protein Names
Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
UniProt Synonym Gene Names
NCBI Summary for NR1H3
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for NR1H3
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism ().
Research Articles on NR1H3
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Products associated with anti-NR1H3 antibody
Pathways associated with anti-NR1H3 antibody
Diseases associated with anti-NR1H3 antibody
Organs/Tissues associated with anti-NR1H3 antibody
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