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anti-NR1I3 antibody :: Rabbit NR1I3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9402493
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR1I3, Polyclonal Antibody

★Popular Item★
 Also Known As   

NR1I3 Antibody

 Product Synonym Names    CAR; CAR1; MB67
 Product Gene Name   

anti-NR1I3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603881
 3D Structure    ModBase 3D Structure for Q14994
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of total NR1I3 protein.
 Purity/Purification    Antibodies were purified by affinity purification using immunogen.
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Recombinant protein of human NR1I3.
 Target Name    NR1I3
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-NR1I3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NR1I3 antibody

   This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene
 Product Categories/Family for anti-NR1I3 antibody    Total protein Ab
 Applications Tested/Suitable for anti-NR1I3 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NR1I3 antibody    Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200
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 Western Blot (WB) of anti-NR1I3 antibody    Western blot analysis of extracts of various cell lines, using NR1I3 antibody.
anti-NR1I3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NR1I3 antibody    Immunohistochemical analysis of paraffin-embedded human esophageal cancer using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NR1I3 antibody    Immunohistochemical analysis of paraffin-embedded human esophagus using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NR1I3 antibody    Immunohistochemical analysis of paraffin-embedded rat kidney using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-NR1I3 antibody    Immunofluorescence analysis of U2OS cell using NR1I3 antibody. Blue: DAPI for nuclear staining.
anti-NR1I3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for NR1I3. It may not necessarily be applicable to this product.
 NCBI GI #    117938729
 NCBI GeneID    9970
 NCBI Accession #    NP_001070937.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001077469.2 [Other Products]
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 UniProt Primary Accession #    Q14994 [Other Products]
 UniProt Secondary Accession #    Q0VAC9; Q4U0F0; E9PB75; E9PC13; E9PDU3; E9PGH6; E9PH10; E9PHC8; E9PHN4; F1D8Q0; F1D8Q1 [Other Products]
 UniProt Related Accession #    Q14994 [Other Products]
 Molecular Weight    SDS-PAGE: 39kD
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 NCBI Official Full Name    nuclear receptor subfamily 1 group I member 3 isoform 6
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group I, member 3
 NCBI Official Symbol    NR1I3 [Similar Products]
 NCBI Official Synonym Symbols   
CAR; CAR1; MB67
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 1 group I member 3
 UniProt Protein Name    Nuclear receptor subfamily 1 group I member 3
 UniProt Synonym Protein Names   
Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR1I3 [Similar Products]
 UniProt Synonym Gene Names    CAR; Constitutive active response; CAR [Similar Products]
 UniProt Entry Name    NR1I3_HUMAN
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 NCBI Summary for NR1I3    This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NR1I3    NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; androgen receptor activity; DNA binding; zinc ion binding; transcription coactivator activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of transcription, DNA-dependent; signal transduction
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 Research Articles on NR1I3    1. Suggest that PXR and CAR double humanized mice are more sensitive rifampcin induction of cytochrome P450 and UDP-glucuronosyltransferases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR1I3 antibodyPathways associated with anti-NR1I3 antibody
 Reference Product  PubMed Publications
 CYP3A4 antibody  >32 publications with NR1I3 and CYP3A4
 CYP2B6 antibody  >28 publications with NR1I3 and CYP2B6
 CYP2E1 antibody  >3 publications with NR1I3 and CYP2E1
 CYP1A2 antibody  >3 publications with NR1I3 and CYP1A2
 RXRA antibody  >2 publications with NR1I3 and RXRA
 THRSP antibody  >1 publications with NR1I3 and THRSP
 Products by Pathway  Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with anti-NR1I3 antibodyOrgans/Tissues associated with anti-NR1I3 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >17 publications with NR1I3 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with NR1I3 and Carcinoma, Hepatocellular
 Fatty Liver Antibodies  >7 publications with NR1I3 and Fatty Liver
 Obesity Antibodies  >7 publications with NR1I3 and Obesity
 Liver Neoplasms Antibodies  >7 publications with NR1I3 and Liver Neoplasms
 Cholestasis Antibodies  >7 publications with NR1I3 and Cholestasis
 Diabetes Mellitus Antibodies  >6 publications with NR1I3 and Diabetes Mellitus
 Inflammation Antibodies  >5 publications with NR1I3 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with NR1I3 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >3 publications with NR1I3 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >70 publications with NR1I3 and Liver
 Brain Antibodies  >8 publications with NR1I3 and Brain
 Kidney Antibodies  >6 publications with NR1I3 and Kidney
 Muscle Antibodies  >1 publications with NR1I3 and Muscle
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