NP_001070937.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 39 kDa Predicted: 40 kDa
NCBI Official Full Name
nuclear receptor subfamily 1 group I member 3 isoform 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 1 group I member 3
NCBI Protein Information
nuclear receptor subfamily 1 group I member 3
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 3
UniProt Synonym Protein Names
Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67
UniProt Synonym Gene Names
NCBI Summary for NR1I3
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NR1I3
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Research Articles on NR1I3
Precautions
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Products associated with anti-NR1I3 antibody
Pathways associated with anti-NR1I3 antibody
Diseases associated with anti-NR1I3 antibody
Organs/Tissues associated with anti-NR1I3 antibody
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