NP_001035199.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nuclear respiratory factor 1 isoform 1
NCBI Official Synonym Full Names
nuclear respiratory factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear respiratory factor 1
UniProt Protein Name
Nuclear respiratory factor 1
UniProt Synonym Protein Names
Alpha palindromic-binding protein; Alpha-pal
UniProt Synonym Gene Names
UniProt Entry Name
NRF1_HUMAN
NCBI Summary for NRF1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
UniProt Comments for NRF1
NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 7q32
Cellular Component: nucleoplasm; cytoplasm
Biological Process: mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; organelle organization and biogenesis; response to lipopolysaccharide; cellular lipid metabolic process; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; response to folic acid; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus
Product References and Citations for anti-NRF1 antibody
Gonen, N., et al. J. Biol. Chem. 285(44):33602-33613(2010) Zhang, Y., et al. Biochem. J. 430(3):497-510(2010) Shao, D., et al. Mitochondrion 10(5):516-527(2010) Adam, T., et al. Biochem. Biophys. Res. Commun. 398(3):495-499(2010) Spelbrink, J.N., et al. Hum. Mol. Genet. 4(9):1591-1596(1995)
Research Articles on NRF1
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Products associated with anti-NRF1 antibody
Diseases associated with anti-NRF1 antibody
Organs/Tissues associated with anti-NRF1 antibody
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