NP_003864.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
neuropilin-1 isoform b
NCBI Official Synonym Full Names
neuropilin 1
NCBI Official Synonym Symbols
NP1; NRP; BDCA4; CD304; VEGF165R [Similar Products]
NCBI Protein Information
neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor
UniProt Protein Name
Neuropilin-1
UniProt Synonym Protein Names
Vascular endothelial cell growth factor 165 receptor
UniProt Synonym Gene Names
UniProt Entry Name
NRP1_HUMAN
NCBI Summary for NRP-1
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for NRP-1
Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform ofPGF, The VEGF-165 isoform ofVEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Subunit structure: Homodimer, and heterodimer with NRP2. Interacts with FER
By similarity. Binds PLXNB1. Ref.10 Ref.16
Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Sequence similarities: Belongs to the neuropilin family.Contains 2 CUB domains.Contains 2 F5/8 type C domains.Contains 1 MAM domain.
Research Articles on NRP-1
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Products associated with anti-NRP-1 antibody
Pathways associated with anti-NRP-1 antibody
Diseases associated with anti-NRP-1 antibody
Organs/Tissues associated with anti-NRP-1 antibody
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