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anti-NT-proBNP antibody :: Rabbit anti-Human NT-proBNP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715412
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NT-proBNP, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human NT-proBNP polyclonal Antibody

 Product Gene Name   

anti-NT-proBNP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS715412 Technical Datasheet    Technical Datasheet PDF
 OMIM    600295
 3D Structure    ModBase 3D Structure for P16860
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    PBS
 Conjugate    Non-conjugated
 Immunogen    Recombinant human NT-proBNP protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18814 / sc-18813 / sc-20159
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NT-proBNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NT-proBNP antibody

   Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
 Applications Tested/Suitable for anti-NT-proBNP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-NT-proBNP antibody    Western blot
All lanes: NT-proBNP antibody at 2ug/ml+Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 15kDa
Observed band size: 15kDa

anti-NT-proBNP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NT-proBNP antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS715412 at dilution 1:100
anti-NT-proBNP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NT-proBNP antibody    Immunohistochemistry of paraffin-embedded human heart tissue using MBS715412 at dilution 1:100
anti-NT-proBNP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NT-proBNP. It may not necessarily be applicable to this product.
 NCBI GI #    4505433
 NCBI GeneID    4879
 NCBI Accession #    NP_002512.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002521.2 [Other Products]
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 UniProt Primary Accession #    P16860 [Other Products]
 UniProt Secondary Accession #    Q6FGY0; Q9P2Q7; B0ZBE9 [Other Products]
 UniProt Related Accession #    P16860 [Other Products]
 Molecular Weight    14,726 Da
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 NCBI Official Full Name    natriuretic peptides B preproprotein
 NCBI Official Synonym Full Names    natriuretic peptide B
 NCBI Official Symbol    NPPB [Similar Products]
 NCBI Official Synonym Symbols   
BNP
[Similar Products]
 NCBI Protein Information    natriuretic peptides B
 UniProt Protein Name    Natriuretic peptides B
 UniProt Synonym Protein Names   
Gamma-brain natriuretic peptide
 UniProt Gene Name    NPPB [Similar Products]
 UniProt Synonym Gene Names    BNP(1-32); BNP-32 [Similar Products]
 UniProt Entry Name    ANFB_HUMAN
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 NCBI Summary for NT-proBNP    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
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 UniProt Comments for NT-proBNP    NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Secreted; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: extracellular region; extracellular space; protein complex

Molecular Function: diuretic hormone activity; hormone activity; protein binding; receptor binding

Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of angiogenesis; negative regulation of cell growth; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation
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 Research Articles on NT-proBNP    1. Data suggest that, compared with subjects without any component of MetS (metabolic syndrome), subjects with uncomplicated MetS (without cardiovascular disease, chronic kidney disease, or diabetes) exhibit up-regulation of circulating NT-proBNP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NT-proBNP antibodyPathways associated with anti-NT-proBNP antibody
 Reference Product  PubMed Publications
 NPPA antibody  >49 publications with NT-proBNP and NPPA
 NPR1 antibody  >8 publications with NT-proBNP and NPR1
 NPR3 antibody  >8 publications with NT-proBNP and NPR3
 NPR2 antibody  >5 publications with NT-proBNP and NPR2
 CYP1A2 antibody  >1 publications with NT-proBNP and CYP1A2
 ATF2 antibody  >1 publications with NT-proBNP and ATF2
 IDE antibody  >1 publications with NT-proBNP and IDE
 Products by Pathway  Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
Diseases associated with anti-NT-proBNP antibodyOrgans/Tissues associated with anti-NT-proBNP antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >144 publications with NT-proBNP and Fibrosis
 Cardiovascular Diseases Antibodies  >84 publications with NT-proBNP and Cardiovascular Diseases
 Heart Diseases Antibodies  >46 publications with NT-proBNP and Heart Diseases
 Hypertension Antibodies  >29 publications with NT-proBNP and Hypertension
 Hypertrophy Antibodies  >22 publications with NT-proBNP and Hypertrophy
 Heart Failure Antibodies  >22 publications with NT-proBNP and Heart Failure
 Edema Antibodies  >17 publications with NT-proBNP and Edema
 Inflammation Antibodies  >15 publications with NT-proBNP and Inflammation
 Myocardial Infarction Antibodies  >14 publications with NT-proBNP and Myocardial Infarction
 Necrosis Antibodies  >13 publications with NT-proBNP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >146 publications with NT-proBNP and Kidney
 Heart Antibodies  >99 publications with NT-proBNP and Heart
 Lung Antibodies  >63 publications with NT-proBNP and Lung
 Liver Antibodies  >44 publications with NT-proBNP and Liver
 Pancreas Antibodies  >29 publications with NT-proBNP and Pancreas
 Embryonic Tissue Antibodies  >16 publications with NT-proBNP and Embryonic Tissue
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