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anti-SCNN1A antibody :: Rabbit Na+ Channel Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS610104
Unit / Price
0.2 mg  /  $705 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Na+ Channel (SCNN1A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Na+ Channel (III-IV loop)

 Product Synonym Names    Anti -Na+ Channel (III-IV loop)
 Product Gene Name   

anti-SCNN1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6456009..6486523, complement). Location: 12p13
 OMIM    264350
 3D Structure    ModBase 3D Structure for P37088
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    Recognizes the vertebrate sodium channel intracellular III-IV loop at ~ 220kDa. Species crossreactivity: Expected for all vertebrates
 Purity/Purification    Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.05% sodium azide, 30% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    KLH conjugated synthetic peptide 'EOIII' (TEEQKKYYNAMKKLGSKKC) corresponding to a highly conserved segment in the intracellular III-IV loop, which to date, is identical in all known vertebrates.
 Positive Control    Rat brain Microsomal Lysate.
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 Preparation and Storage    May be stored at 4 degree C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SCNN1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SCNN1A antibody

   The Na + channel protein mediates the voltage-dependent sodium ion permeability of excitable membranes by forming a sodium-selective channel through which Na + ions may pass in accordance with their electrochemical gradient. The Na + channel protein contains four internal repeats, each with five hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). The S4 segments are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
 Product Categories/Family for anti-SCNN1A antibody    Antibodies; Abs to Ion Channel
 Applications Tested/Suitable for anti-SCNN1A antibody   

Western Blot (WB), Immunoprecipitation (IP), Imunohistochemistry (IHC)

 Application Notes for anti-SCNN1A antibody    Western Blot: 0.5-2ug/ml detected Sodium Channel (III-IV) Linker Region) in Rat brain microsomal tissue extract. 40ug rat brain microsomal tissue extract was resolved by electrophoresis, transferred to nitrocellulose and probed with MBS610104 (2ug/ml). Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system.
Note: Do not boil tissue extracts, but instead heat to 37 degree C for 15-30 minutes prior to loading the gel.
immunoprecipitation: 1-4ug immunoprecipitated Sodium Channel (III-IV Linker Region) from 400ug of Rat Brain Microsomal Tissue extract.
Optimal dilutions to be determined by the researcher.
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 Test Data of anti-SCNN1A antibody    Mouse sciatic nerves stained with MBS610104 at 20ug/ml.
anti-SCNN1A antibody Test Data image
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 Western Blot of anti-SCNN1A antibody    WB analysis of 20ug rat brain microsomal preparation using 0.5-2ug/ml of MBS610104.
anti-SCNN1A antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for SCNN1A. It may not necessarily be applicable to this product.
 NCBI GI #    493605
 NCBI GeneID    6337
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 UniProt Primary Accession #    P37088 [Other Products]
 UniProt Secondary Accession #    O43271; Q6GSQ6; Q9UM64; A5X2U9; C5HTZ0 [Other Products]
 UniProt Related Accession #    P37088; Q6UP09 [Other Products]
 Molecular Weight    75,704 Da [Similar Products]
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 NCBI Official Full Name    Na+ channel
 NCBI Official Synonym Full Names    sodium channel, nonvoltage-gated 1 alpha
 NCBI Official Symbol    SCNN1A [Similar Products]
 NCBI Official Synonym Symbols   
BESC2; ENaCa; SCNEA; SCNN1; FLJ21883; ENaCalpha
[Similar Products]
 NCBI Protein Information    amiloride-sensitive sodium channel subunit alpha; alpha-ENaC; alpha-NaCH; alpha ENaC-2; OTTHUMP00000238446; OTTHUMP00000238447; OTTHUMP00000238448; OTTHUMP00000238449; OTTHUMP00000238451; epithelial Na(+) channel subunit alpha; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive epithelial sodium channel alpha subunit
 UniProt Protein Name    Amiloride-sensitive sodium channel subunit alpha
 UniProt Synonym Protein Names   
Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA
 Protein Family    Amiloride-sensitive sodium channel
 UniProt Gene Name    SCNN1A [Similar Products]
 UniProt Synonym Gene Names    SCNN1 [Similar Products]
 UniProt Entry Name    SCNNA_HUMAN
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 NCBI Summary for SCNN1A    Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
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 UniProt Comments for SCNN1A    ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Channel, sodium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cortical actin cytoskeleton; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol; external side of plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding; actin binding

Biological Process: sensory perception of taste; sodium ion transport; response to stimulus; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport

Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 2; Pseudohypoaldosteronism, Type I, Autosomal Recessive
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 Research Articles on SCNN1A    1. Identify the specific domains of epithelial sodium channels that are responsible for the differences in the response to flow of alphabetagamma and deltabetagamma channels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCNN1A antibodyPathways associated with anti-SCNN1A antibody
 Reference Product  PubMed Publications
 SCNN1B antibody  >31 publications with SCNN1A and SCNN1B
 SCNN1G antibody  >28 publications with SCNN1A and SCNN1G
 NEDD4 antibody  >3 publications with SCNN1A and NEDD4
 NEDD4L antibody  >1 publications with SCNN1A and NEDD4L
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
Diseases associated with anti-SCNN1A antibodyOrgans/Tissues associated with anti-SCNN1A antibody
 Disease Name  Pubmed Publications
 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 2 Antibodies  >55 publications with SCNN1A and BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 2
 Hypertension Antibodies  >17 publications with SCNN1A and Hypertension
 Genetic Diseases, Inborn Antibodies  >15 publications with SCNN1A and Genetic Diseases, Inborn
 Female Urogenital Diseases Antibodies  >13 publications with SCNN1A and Female Urogenital Diseases
 Kidney Diseases Antibodies  >13 publications with SCNN1A and Kidney Diseases
 Pseudohypoaldosteronism Antibodies  >12 publications with SCNN1A and Pseudohypoaldosteronism
 Fibrosis Antibodies  >9 publications with SCNN1A and Fibrosis
 Lung Diseases Antibodies  >9 publications with SCNN1A and Lung Diseases
 Cardiovascular Diseases Antibodies  >9 publications with SCNN1A and Cardiovascular Diseases
 Cystic Fibrosis Antibodies  >9 publications with SCNN1A and Cystic Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >25 publications with SCNN1A and Kidney
 Lung Antibodies  >17 publications with SCNN1A and Lung
 Blood Antibodies  >15 publications with SCNN1A and Blood
 Embryonic Tissue Antibodies  >4 publications with SCNN1A and Embryonic Tissue
 Liver Antibodies  >2 publications with SCNN1A and Liver
 Placenta Antibodies  >2 publications with SCNN1A and Placenta
 Testis Antibodies  >2 publications with SCNN1A and Testis
 Intestine Antibodies  >2 publications with SCNN1A and Intestine
 Thyroid Antibodies  >1 publications with SCNN1A and Thyroid
 Brain Antibodies  >1 publications with SCNN1A and Brain
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