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anti-NPR2 antibody :: Rabbit Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS315495 anti-NPR2 antibody
Unit / Price
0.02 mL  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302) (NPR2), Polyclonal Antibody

 Also Known As   

Rabbit anti Human NPR-B (a.a. 288-302)

 Product Synonym Names    Rabbit Antibody to Human Natriuretic Peptide Receptor B (NPR-B) (amino acids 288-302)
 Product Gene Name   

anti-NPR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (35792406..35809728). Location: 9p21-p12
 OMIM    108961
 3D Structure    ModBase 3D Structure for P20594
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302)
Synthetic human NPR-B peptide (a.a. 288-302)
 Form/Format    Neat, Lyophilized.
Reconstitute in 20ul double distilled water.
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 Immunogen    Synthetic human NPR-B (a.a. 288-302) poly Lys. conjugated (QNRLLIRAREDFGVE)
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Store lyophilized product at 2 to 8 degree C. After reconstitution, store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NPR2 antibody    Polyclonal Antibodies to Cardiac Markers
 Applications Tested/Suitable for anti-NPR2 antibody   

Western Blot

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NCBI/Uniprot data below describe general gene information for NPR2. It may not necessarily be applicable to this product.
 NCBI GI #    4580422
 NCBI GeneID    4882
 NCBI Accession #    NP_003986.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003995.3 [Other Products]
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 UniProt Primary Accession #    P20594 [Other Products]
 UniProt Secondary Accession #    O60871; Q4VAK7; Q5TCV2; Q8TA93; Q9UQ50; B0ZBF2; B0ZBF3; D3DRP3; D3DRP4 [Other Products]
 UniProt Related Accession #    P20594 [Other Products]
 Molecular Weight    117,022 Da [Similar Products]
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 NCBI Official Full Name    atrial natriuretic peptide receptor 2
 NCBI Official Synonym Full Names    natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
 NCBI Official Symbol    NPR2 [Similar Products]
 NCBI Official Synonym Symbols   
AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
[Similar Products]
 NCBI Protein Information    atrial natriuretic peptide receptor 2; GC-B; ANP-B; NPR-B; ANPR-B; OTTHUMP00000021345; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B
 UniProt Protein Name    Atrial natriuretic peptide receptor 2
 UniProt Synonym Protein Names   
Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B
 Protein Family    Nitrogen permease regulator
 UniProt Gene Name    NPR2 [Similar Products]
 UniProt Synonym Gene Names    ANPRB [Similar Products]
 UniProt Entry Name    ANPRB_HUMAN
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 NCBI Summary for NPR2    This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq]
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 UniProt Comments for NPR2    Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Ref.9 Ref.11

Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by CNP

Involvement in disease: Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [

MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. Ref.11

Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.
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 Research Articles on NPR2    1. Data show that serum B-type natriuretic peptide strongly correlates with new-onset heart failure development at the optimal cut-off value of 175 pg/mL.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPR2 antibodyPathways associated with anti-NPR2 antibody
 Reference Product  PubMed Publications
 NPPC antibody  >5 publications with NPR2 and NPPC
 Products by Pathway  Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
Diseases associated with anti-NPR2 antibodyOrgans/Tissues associated with anti-NPR2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with NPR2 and Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with NPR2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >4 publications with NPR2 and Heart Diseases
 Acromesomelic dysplasia, Maroteaux type Antibodies  >4 publications with NPR2 and Acromesomelic dysplasia, Maroteaux type
 Hypertension Antibodies  >2 publications with NPR2 and Hypertension
 Heart Failure Antibodies  >2 publications with NPR2 and Heart Failure
 Lung Neoplasms Antibodies  >2 publications with NPR2 and Lung Neoplasms
 Lung Diseases Antibodies  >2 publications with NPR2 and Lung Diseases
 Intestinal Diseases Antibodies  >1 publications with NPR2 and Intestinal Diseases
 Pain, Postoperative Antibodies  >1 publications with NPR2 and Pain, Postoperative
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with NPR2 and Brain
 Bone Antibodies  >7 publications with NPR2 and Bone
 Lung Antibodies  >2 publications with NPR2 and Lung
 Connective Tissue Antibodies  >2 publications with NPR2 and Connective Tissue
 Heart Antibodies  >2 publications with NPR2 and Heart
 Pituitary Gland Antibodies  >1 publications with NPR2 and Pituitary Gland
 Intestine Antibodies  >1 publications with NPR2 and Intestine
 Kidney Antibodies  >1 publications with NPR2 and Kidney
 Ear Antibodies  >1 publications with NPR2 and Ear
 Ovary Antibodies  >1 publications with NPR2 and Ovary
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