AAA41201.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
123,467 Da
NCBI Official Full Name
guanylyl cyclase
NCBI Official Synonym Full Names
guanylate cyclase 2C
NCBI Official Synonym Symbols
NCBI Protein Information
heat-stable enterotoxin receptor
UniProt Protein Name
Heat-stable enterotoxin receptor
UniProt Synonym Protein Names
Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase
UniProt Synonym Gene Names
UniProt Entry Name
GUC2C_RAT
NCBI Summary for PGCC
guanylyl cyclase; functions as receptor for heat-stable enterotoxin responsible for acute diarrhea [RGD, Feb 2006]
UniProt Comments for PGCC
GUCY2C: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. Defects in GUCY2C are the cause of diarrhea type 6 (DIAR6). A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small-bowel obstruction, and esophagitis. Defects in GUCY2C are a cause of meconium ileus (MECIL). A condition characterized by a intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Nucleotide Metabolism - purine; Lyase; Protein kinase, RGC; EC 4.6.1.2; Kinase, protein; Protein kinase, dual-specificity (receptor); Membrane protein, integral; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family
Cellular Component: endoplasmic reticulum membrane; guanylate cyclase complex, soluble; integral to membrane; plasma membrane
Molecular Function: adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; protein kinase activity; toxin binding
Biological Process: cGMP biosynthetic process; protein amino acid phosphorylation; regulation of cell proliferation; response to toxin; signal transduction
Research Articles on PGCC
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Pathways associated with anti-PGCC antibody
Diseases associated with anti-PGCC antibody
Organs/Tissues associated with anti-PGCC antibody
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