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anti-Slc11a1 antibody :: Rabbit anti-Mouse, Rat Natural Resistance Associated Macrophage Protein with IRE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617851 anti-Slc11a1 antibody
Unit / Price
0.05 mg  /  $455 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Natural Resistance Associated Macrophage Protein with IRE (Slc11a1), Polyclonal Antibody

 Also Known As   

Natural Resistance Associated Macrophage Protein with IRE (Nramp2 with IRE) (formerly M1252-06)

 Product Synonym Names    Anti -Natural Resistance Associated Macrophage Protein with IRE (Nramp2 with IRE) (formerly M1252-06)
 Product Gene Name   

anti-Slc11a1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000067.5 (74421777..74432625). Location: 1 C3; 1 39.2 cM
 3D Structure    ModBase 3D Structure for P41251
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Specificity    Recognizes rat NRAMP2 with IRE
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 0.1% sodium azide.
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 Immunogen    Synthetic peptide corresponding to 17aa located near the C-terminal, cytoplasmic domain of rat NRAMP2 conjugated with KLH. This sequence is 100% homologous with mouse Nramp2 with IRE and is absent in NRAMP2 without IRE. No significant sequence homology exists with NRAMP1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Slc11a1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Slc11a1 antibody

   Iron is an essential element for a variety physiological process. A variety of proteins are involved in the transport of iron. Most dietary iron exists in the form of ferric iron complexes which must be reduced to yield ferrous ion before it can be taken up by protein transporters such as DCT1 (divalent cation transporter)/NRAMP2/DMT1. These transporters are especially active in small intestine where most dietary iron absorption is conducted. Ferrous Fe (II) is very unstable at physiological pH and quickly oxidized to ferric Fe (III). Highly specialized transmembrane electron transport system, maintained by ferric reductases, is required for the availability of intracellular ferrous ion. A second member of NRAMP family, termed NRAMP2/DMT/DCT1 (Divalent Metal ion Transporter 1 or Divalent Cation Transporter 1), has been identified (human, rat and mouse 568aa, ~65% identity with NRAMP1). NRAMP2 expression is more ubiquitous and has been detected in most tissues. NRAMP2 expression is more pronounced in brain, thymus, proximal intestine, kidney and bone marrow. It is dramatically up regulated by iron starvation in the intestine. NRAMP2 gene produces two alternatively spliced transcripts generated by alternative use of two 3' exons encoding distinct C-termini of the protein as well as distinct 3' untranslated regions (UTRs). One Nramp2 mRNA contains an iron-responsive element (IRE) in its 3'UTR. The IRE is an RNA secondary structure present in the 5'- or the 3'-UTR of animal mRNAs encoding proteins involved in iron metabolism. The second Nramp2 splice isoform (without-IRE, isoform II) encodes a protein in which the C-terminal 18aa of the IRE form (with IRE, isoform I) is replaced by a novel 25aa segment and codes for a distinct 3' UTR lacking the IRE. The two isoforms are differentially localized and regulated in GI tract and kidney. It has been demonstrated that the Nramp2 gene is mutated (Gly185 to Arg at TM4) in both the mk and Belgrade (b) animal models exhibiting a severe microcytic hypochromic anemia marked by a defect in iron absorption by intestinal cells and in erythroid iron use.
 Product Categories/Family for anti-Slc11a1 antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-Slc11a1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-Slc11a1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml (ECL).
ELISA: 0.5-1ug/ml. Coat ELISA plates at 1ug/ml of Control Peptide.
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NCBI/Uniprot data below describe general gene information for Slc11a1. It may not necessarily be applicable to this product.
 NCBI GI #    505156
 NCBI GeneID    18173
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 UniProt Primary Accession #    P41251 [Other Products]
 UniProt Secondary Accession #    Q3TB84 [Other Products]
 UniProt Related Accession #    P41251 [Other Products]
 Molecular Weight    59,741 Da [Similar Products]
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 NCBI Official Full Name    natural resistance associated macrophage protein
 NCBI Official Synonym Full Names    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
 NCBI Official Symbol    Slc11a1 [Similar Products]
 NCBI Official Synonym Symbols   
Bcg; Ity; Lsh; ity; Nramp; Nramp1; MGC129156; MGC129157
[Similar Products]
 NCBI Protein Information    natural resistance-associated macrophage protein 1; NRAMP 1; OTTMUSP00000017968; host resistance locus Bcg/Ity/Lsh
 UniProt Protein Name    Natural resistance-associated macrophage protein 1
 Protein Family    Natural resistance-associated macrophage protein
 UniProt Gene Name    Slc11a1 [Similar Products]
 UniProt Synonym Gene Names    Bcg; Ity; Lsh; Nramp1 [Similar Products]
 UniProt Entry Name    NRAM1_MOUSE
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 UniProt Comments for Slc11a1    SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.

Protein type: Transporter, SLC family; Cell surface; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Vesicle

Cellular Component: phagocytic vesicle membrane; cell surface; membrane; lysosome; late endosome; integral to membrane; plasma membrane; endosome membrane; vacuole

Molecular Function: transition metal ion transmembrane transporter activity; protein homodimerization activity; transporter activity; manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity

Biological Process: respiratory burst; positive regulation of T-helper 1 type immune response; wound healing; cellular iron ion homeostasis; positive regulation of dendritic cell antigen processing and presentation; manganese ion transport; response to lipopolysaccharide; defense response to Gram-negative bacterium; antigen processing and presentation of peptide antigen; vacuolar acidification; nitrite transport; T cell cytokine production; T cell proliferation during immune response; transport; positive regulation of phagocytosis; interleukin-3 production; inflammatory response; positive regulation of cytokine production; mRNA stabilization; MAPKKK cascade; L-arginine import; defense response to protozoan; iron ion transport; interleukin-2 production; phagocytosis; iron ion homeostasis; macrophage activation; cellular cadmium ion homeostasis; MHC class II biosynthetic process; positive regulation of interferon-gamma production; response to bacterium; protein import into nucleus, translocation; defense response to bacterium; negative regulation of cytokine production; activation of protein kinase activity; ion transport; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on Slc11a1    1. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Slc11a1 antibodyDiseases associated with anti-Slc11a1 antibody
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Disease Name  Pubmed Publications
 Bacterial Infections Antibodies  >81 publications with Slc11a1 and Bacterial Infections
 Tuberculosis Antibodies  >37 publications with Slc11a1 and Tuberculosis
 Inflammation Antibodies  >19 publications with Slc11a1 and Inflammation
 Protozoan Infections Antibodies  >11 publications with Slc11a1 and Protozoan Infections
 Inflammatory Bowel Diseases Antibodies  >8 publications with Slc11a1 and Inflammatory Bowel Diseases
 Colitis Antibodies  >7 publications with Slc11a1 and Colitis
 Diabetes Mellitus Antibodies  >7 publications with Slc11a1 and Diabetes Mellitus
 Arthritis, Rheumatoid Antibodies  >7 publications with Slc11a1 and Arthritis, Rheumatoid
 Diabetes Mellitus, Type 1 Antibodies  >7 publications with Slc11a1 and Diabetes Mellitus, Type 1
 Leishmaniasis, Visceral Antibodies  >6 publications with Slc11a1 and Leishmaniasis, Visceral
Organs/Tissues associated with anti-Slc11a1 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >13 publications with Slc11a1 and Spleen
 Liver Antibodies  >8 publications with Slc11a1 and Liver
 Intestine Antibodies  >6 publications with Slc11a1 and Intestine
 Lung Antibodies  >5 publications with Slc11a1 and Lung
 Bone Marrow Antibodies  >5 publications with Slc11a1 and Bone Marrow
 Bone Antibodies  >5 publications with Slc11a1 and Bone
 Brain Antibodies  >3 publications with Slc11a1 and Brain
 Skin Antibodies  >3 publications with Slc11a1 and Skin
 Pancreas Antibodies  >1 publications with Slc11a1 and Pancreas
 Eye Antibodies  >1 publications with Slc11a1 and Eye
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