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anti-DCC antibody :: anti-Mouse, Human Netrin receptor DCC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857291
Testing Data
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Netrin receptor DCC, Polyclonal Antibody

 Also Known As   

Netrin receptor DCC Antibody

 Product Gene Name   

anti-DCC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120470
 3D Structure    ModBase 3D Structure for P43146
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Mouse, Human
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 Specificity    This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to AIRE.
 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Cellular Localization    Cell Membrane
 Positive Control    Human brain, mouse brain
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 Preparation and Storage    Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-DCC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DCC antibody

   Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.
 Product Categories/Family for anti-DCC antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Application Notes for anti-DCC antibody    WB: 1:500-1:1,000
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 Testing Data of anti-DCC antibody    Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
anti-DCC antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for DCC. It may not necessarily be applicable to this product.
 NCBI GI #    110431348
 NCBI GeneID    1630
 NCBI Accession #    NP_005206.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005215.3 [Other Products]
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 UniProt Primary Accession #    P43146 [Other Products]
 UniProt Secondary Accession #    P70211 [Other Products]
 UniProt Related Accession #    P43146 [Other Products]
 Molecular Weight    90kDa [Similar Products]
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 NCBI Official Full Name    netrin receptor DCC
 NCBI Official Synonym Full Names    DCC netrin 1 receptor
 NCBI Official Symbol    DCC [Similar Products]
 NCBI Official Synonym Symbols   
CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
[Similar Products]
 NCBI Protein Information    netrin receptor DCC
 UniProt Protein Name    Netrin receptor DCC
 UniProt Synonym Protein Names   
Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
 Protein Family    Netrin receptor
 UniProt Gene Name    DCC [Similar Products]
 UniProt Synonym Gene Names    IGDCC1 [Similar Products]
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 NCBI Summary for DCC    This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
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 UniProt Comments for DCC    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
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 Research Articles on DCC    1. rs2229080 and rs7504990 polymorphisms in DCC might be related with breast cancer susceptibility in Chinese women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DCC antibodyPathways associated with anti-DCC antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >9 publications with DCC and CASP3
 PTK2 antibody  >4 publications with DCC and PTK2
 NTN1 antibody  >4 publications with DCC and NTN1
 CASP9 antibody  >4 publications with DCC and CASP9
 NCK1 antibody  >2 publications with DCC and NCK1
 MAZ antibody  >2 publications with DCC and MAZ
 MAPK3 antibody  >2 publications with DCC and MAPK3
 APPL1 antibody  >1 publications with DCC and APPL1
 SIAH2 antibody  >1 publications with DCC and SIAH2
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 DCC Mediated Attractive Signaling Pathway antibodies  DCC Mediated Attractive Signaling Pathway Diagram
 DSCAM Interactions Pathway antibodies  DSCAM Interactions Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-DCC antibodyOrgans/Tissues associated with anti-DCC antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1004 publications with DCC and Neoplasms
 Carcinoma Antibodies  >506 publications with DCC and Carcinoma
 Colorectal Neoplasms Antibodies  >409 publications with DCC and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >261 publications with DCC and Breast Neoplasms
 Adenocarcinoma Antibodies  >206 publications with DCC and Adenocarcinoma
 Endocrine Gland Neoplasms Antibodies  >83 publications with DCC and Endocrine Gland Neoplasms
 Respiratory Tract Diseases Antibodies  >65 publications with DCC and Respiratory Tract Diseases
 Ovarian Neoplasms Antibodies  >50 publications with DCC and Ovarian Neoplasms
 Pancreatic Neoplasms Antibodies  >44 publications with DCC and Pancreatic Neoplasms
 Lung Diseases Antibodies  >42 publications with DCC and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >213 publications with DCC and Brain
 Lung Antibodies  >62 publications with DCC and Lung
 Embryonic Tissue Antibodies  >55 publications with DCC and Embryonic Tissue
 Bone Antibodies  >48 publications with DCC and Bone
 Kidney Antibodies  >39 publications with DCC and Kidney
 Esophagus Antibodies  >21 publications with DCC and Esophagus
 Connective Tissue Antibodies  >11 publications with DCC and Connective Tissue
 Ear Antibodies  >9 publications with DCC and Ear
 Testis Antibodies  >5 publications with DCC and Testis
 Thymus Antibodies  >3 publications with DCC and Thymus
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