NP_037481.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,856 Da
NCBI Official Full Name
neudesin
NCBI Official Synonym Full Names
neudesin neurotrophic factor
NCBI Protein Information
neudesin
UniProt Protein Name
Neudesin
UniProt Synonym Protein Names
Cell immortalization-related protein 2; Neuron-derived neurotrophic factor; Protein GIG47
UniProt Synonym Gene Names
UniProt Entry Name
NENF_HUMAN
NCBI Summary for NENF
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
UniProt Comments for NENF
NENF: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. Belongs to the cytochrome b5 family. MAPR subfamily.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component: endomembrane system; extracellular space; membrane; nucleoplasm; nucleus
Molecular Function: growth factor activity; metal ion binding
Biological Process: negative regulation of appetite; positive regulation of MAPKKK cascade
Research Articles on NENF
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Diseases associated with anti-NENF antibody
Organs/Tissues associated with anti-NENF antibody
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