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anti-NRXN1 antibody :: Goat Neurexin 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421542
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurexin 1 (NRXN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Neurexin 1 Antibody

 Product Synonym Names    neurexin 1; DKFZp313P2036; NRXN1; FLJ35941; Hs.22998; KIAA0578; neurexin I; neurexin 1 antibody; DKFZp313P2036 antibody; NRXN1 antibody; FLJ35941 antibody; Hs.22998 antibody; KIAA0578 antibody; neurexin I antibody; Neurexin 1; Neurexin 1
 Product Gene Name   

anti-NRXN1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Neurexin 1 peptide (MBS426477) is used for blocking the activity of Neurexin 1 antibody (MBS421542)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KEKQPSSAKS SNKN
 OMIM    600565
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KEKQPSSAKSSNKN, from the C Terminus of the protein sequence according to NP_004792.1 ; NP_620072.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NRXN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NRXN1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-NRXN1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: In transfected HEK293 transiently expressing full-length Human NRXN1 (myc and DYKDDDDK tagged), bands of approx.75 and 60kDa were observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-DYKDDDDK tag antibody. Recommended concentration, 0.5-1ug/ml.
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 Western Blot (WB) of anti-NRXN1 antibody    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human NRXN1 with DYKDDDDK tag probed in Lane A and probed with anti- DYKDDDDK Tag (1/3000) in lane C. Mock-transfected HEK293 probed in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
anti-NRXN1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NRXN1. It may not necessarily be applicable to this product.
 NCBI GI #    14149613
 NCBI GeneID    9378
 NCBI Accession #    NP_004792.1 [Other Products]
 NCBI Related Accession #    NP_620072.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004801.4 [Other Products]
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 UniProt Secondary Accession #    O60323; Q53TJ9; Q53TQ1; Q5HYI0; Q9C079; Q9C080; Q9C081; Q9H3M2; Q9UDM6; A7KRL9 [Other Products]
 UniProt Related Accession #    Q9ULB1; P58400 [Other Products]
 Molecular Weight    46,861 Da
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 NCBI Official Full Name    neurexin-1 isoform alpha1
 NCBI Official Synonym Full Names    neurexin 1
 NCBI Official Symbol    NRXN1 [Similar Products]
 NCBI Official Synonym Symbols   
PTHSL2; SCZD17; Hs.22998
[Similar Products]
 NCBI Protein Information    neurexin-1
 UniProt Protein Name    Neurexin-1
 UniProt Synonym Protein Names   
Neurexin I-alpha; Neurexin-1-alpha
 Protein Family    Neurexin
 UniProt Gene Name    NRXN1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0578 [Similar Products]
 UniProt Entry Name    NRX1A_HUMAN
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 NCBI Summary for NRXN1    This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission, and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. The RefSeq project has decided to create only a few representative transcript variants of the multitude that are possible. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2. [provided by RefSeq, Feb 2016]
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 UniProt Comments for NRXN1    NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2p16.3

Cellular Component: cell soma; cell surface; endoplasmic reticulum; integral to plasma membrane; nuclear membrane; plasma membrane; presynaptic membrane; vesicle

Molecular Function: acetylcholine receptor binding; calcium channel regulator activity; calcium ion binding; cell adhesion molecule binding; protein binding; receptor activity

Biological Process: adult behavior; axon guidance; learning; neuromuscular process controlling balance; neuron adhesion; neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; social behavior; synaptic transmission; synaptogenesis; vocal learning

Disease: Chromosome 2p16.3 Deletion Syndrome; Pitt-hopkins-like Syndrome 2
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 Research Articles on NRXN1    1. Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NRXN1 antibodyPathways associated with anti-NRXN1 antibody
 Reference Product  PubMed Publications
 NLGN3 antibody  >14 publications with NRXN1 and NLGN3
 NLGN1 antibody  >11 publications with NRXN1 and NLGN1
 NLGN2 antibody  >6 publications with NRXN1 and NLGN2
 NLGN4X antibody  >5 publications with NRXN1 and NLGN4X
 LRRTM2 antibody  >5 publications with NRXN1 and LRRTM2
 APBA2 antibody  >3 publications with NRXN1 and APBA2
 DAG1 antibody  >1 publications with NRXN1 and DAG1
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Non-integrin Membrane-ECM Interactions Pathway antibodies  Non-integrin Membrane-ECM Interactions Pathway Diagram
Diseases associated with anti-NRXN1 antibodyOrgans/Tissues associated with anti-NRXN1 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >81 publications with NRXN1 and Schizophrenia
 Nervous System Diseases Antibodies  >52 publications with NRXN1 and Nervous System Diseases
 Autism Spectrum Disorder Antibodies  >51 publications with NRXN1 and Autism Spectrum Disorder
 Autistic Disorder Antibodies  >48 publications with NRXN1 and Autistic Disorder
 Intellectual Disability Antibodies  >38 publications with NRXN1 and Intellectual Disability
 Cognition Disorders Antibodies  >14 publications with NRXN1 and Cognition Disorders
 Abnormalities, Multiple Antibodies  >13 publications with NRXN1 and Abnormalities, Multiple
 Language Development Disorders Antibodies  >10 publications with NRXN1 and Language Development Disorders
 Memory Disorders Antibodies  >9 publications with NRXN1 and Memory Disorders
 Learning Disorders Antibodies  >9 publications with NRXN1 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >106 publications with NRXN1 and Nerve
 Brain Antibodies  >71 publications with NRXN1 and Brain
 Embryonic Tissue Antibodies  >6 publications with NRXN1 and Embryonic Tissue
 Eye Antibodies  >3 publications with NRXN1 and Eye
 Muscle Antibodies  >3 publications with NRXN1 and Muscle
 Lung Antibodies  >2 publications with NRXN1 and Lung
 Liver Antibodies  >1 publications with NRXN1 and Liver
 Intestine Antibodies  >1 publications with NRXN1 and Intestine
 Skin Antibodies  >1 publications with NRXN1 and Skin
 Vascular Antibodies  >1 publications with NRXN1 and Vascular
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