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anti-NRXN3 antibody :: Goat Neurexin 3/NRXN3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421727 anti-NRXN3 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurexin 3/NRXN3, Polyclonal Antibody

 Also Known As   

Goat anti-Neurexin 3/NRXN3 Antibody

 Product Synonym Names    NRXN3; neurexin 3; KIAA0743; MGC176711; neurexin III; NRXN3 antibody; neurexin 3 antibody; KIAA0743 antibody; MGC176711 antibody; neurexin III antibody; Neurexin 3; Neurexin 3 / NRXN3
 Product Gene Name   

anti-NRXN3 antibody

[Similar Products]
 Antibody/Peptide Pairs    Neurexin 3 / NRXN3 peptide (MBS425523) is used for blocking the activity of Neurexin 3/NRXN3 antibody (MBS421727)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PQERKDARSQ KNT
 OMIM    600567
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Dog, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PQERKDARSQKNT, from the internal region of the protein sequence according to NP_004787.2.
 Epitope    Internal region
 Note    This antibody is expected to recognize the reported isoform 1 (NP_004787.2).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NRXN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NRXN3 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-NRXN3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 24 kDa band in Human Brain (Cerebellum) lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117 kDa according to NP_004787.2. The 24 kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for NRXN3. It may not necessarily be applicable to this product.
 NCBI GI #    21070969
 NCBI GeneID    9369
 NCBI Accession #    NP_004787.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004796.5 [Other Products]
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 UniProt Secondary Accession #    Q6NUR0; Q8IUD8; A5PKW8; A8MPU5; B3KPM7 [Other Products]
 UniProt Related Accession #    Q9HDB5; Q9Y4C0 [Other Products]
 Molecular Weight    180,599 Da
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 NCBI Official Full Name    neurexin 3 isoform 1
 NCBI Official Synonym Full Names    neurexin 3
 NCBI Official Symbol    NRXN3 [Similar Products]
 NCBI Official Synonym Symbols   
C14orf60
[Similar Products]
 NCBI Protein Information    neurexin 3
 UniProt Protein Name    Neurexin-3-beta
 UniProt Synonym Protein Names   
Neurexin III-beta
 Protein Family    Neurexin
 UniProt Gene Name    NRXN3 [Similar Products]
 UniProt Synonym Gene Names    KIAA0743; NRXN3-CTF [Similar Products]
 UniProt Entry Name    NRX3B_HUMAN
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 NCBI Summary for NRXN3    This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
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 UniProt Comments for NRXN3    NRXN3B: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. {ECO:0000250}. Belongs to the neurexin family. {ECO:0000305}. The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3. Weakly interacts with CBLN1 and CBLN2. Very weak binding, if any, with CBLN4. {ECO:0000250}. 7 isoforms of the human protein are produced by alternative promoter

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to membrane; integral to plasma membrane; protein complex

Molecular Function: calcium channel regulator activity; cell adhesion molecule binding; metal ion binding; receptor activity; transmembrane receptor activity

Biological Process: adult behavior; angiogenesis; axon guidance; learning; neuron adhesion; neurotransmitter secretion; positive regulation of synaptogenesis; signal transduction; social behavior; synaptogenesis
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 Research Articles on NRXN3    1. This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NRXN3 antibodyDiseases associated with anti-NRXN3 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with NRXN3 and Nervous System Diseases
 Substance-Related Disorders Antibodies  >8 publications with NRXN3 and Substance-Related Disorders
 Brain Diseases Antibodies  >6 publications with NRXN3 and Brain Diseases
 Disease Models, Animal Antibodies  >4 publications with NRXN3 and Disease Models, Animal
 Weight Gain Antibodies  >2 publications with NRXN3 and Weight Gain
 Neurobehavioral Manifestations Antibodies  >2 publications with NRXN3 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >2 publications with NRXN3 and Learning Disorders
 Liver Diseases Antibodies  >1 publications with NRXN3 and Liver Diseases
 Lung Neoplasms Antibodies  >1 publications with NRXN3 and Lung Neoplasms
 Cognition Disorders Antibodies  >1 publications with NRXN3 and Cognition Disorders
Organs/Tissues associated with anti-NRXN3 antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >35 publications with NRXN3 and Nerve
 Brain Antibodies  >21 publications with NRXN3 and Brain
 Liver Antibodies  >3 publications with NRXN3 and Liver
 Heart Antibodies  >3 publications with NRXN3 and Heart
 Kidney Antibodies  >2 publications with NRXN3 and Kidney
 Embryonic Tissue Antibodies  >2 publications with NRXN3 and Embryonic Tissue
 Lung Antibodies  >2 publications with NRXN3 and Lung
 Prostate Antibodies  >1 publications with NRXN3 and Prostate
 Placenta Antibodies  >1 publications with NRXN3 and Placenta
 Muscle Antibodies  >1 publications with NRXN3 and Muscle
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