NP_056493.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
neurobeachin isoform 1
NCBI Official Synonym Full Names
neurobeachin
NCBI Official Synonym Symbols
NCBI Protein Information
neurobeachin
UniProt Protein Name
Neurobeachin
UniProt Synonym Protein Names
Lysosomal-trafficking regulator 2; Protein BCL8B
UniProt Synonym Gene Names
UniProt Entry Name
NBEA_HUMAN
NCBI Summary for NBEA
This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
UniProt Comments for NBEA
neurobeachin: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Belongs to the WD repeat neurobeachin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 13q13
Cellular Component: cytosol; endomembrane system; plasma membrane; trans-Golgi network
Molecular Function: protein kinase binding
Biological Process: protein localization
Research Articles on NBEA
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Products associated with anti-NBEA antibody
Diseases associated with anti-NBEA antibody
Organs/Tissues associated with anti-NBEA antibody
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