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anti-NFASC antibody :: Goat Neurofascin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422738
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurofascin (NFASC), Polyclonal Antibody

 Also Known As   

Goat anti-Neurofascin (aa877-890) Antibody

 Product Synonym Names    NFASC; neurofascin; DKFZp686P2250; FLJ46866; KIAA0756; NF; NRCAML; OTTHUMP00000065316; OTTHUMP00000065319; OTTHUMP00000065322; OTTHUMP00000065323; OTTHUMP00000065324; neurofascin homolog; NFASC antibody; neurofascin antibody; DKFZp686P2250 antibody; FLJ46866 antibody; KIAA0756 antibody; NF antibody; NRCAML antibody; OTTHUMP00000065316 antibody; OTTHUMP00000065319 antibody; OTTHUMP00000065323 antibody; OTTHUMP00000065324 antibody; neurofascin homolog antibody; Neurofascin; Neurofascin (aa877-890)
 Product Gene Name   

anti-NFASC antibody

[Similar Products]
 Antibody/Peptide Pairs    Neurofascin peptide (MBS427540) is used for blocking the activity of Neurofascin antibody (MBS422738)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NFSPNQTKFT VQRT
 OMIM    609145
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NFSPNQTKFTVQRT, from the internal region of the protein sequence according to NP_001005388.2; NP_001153803.1; NP_001153804.1; NP_055905.2;.
 Epitope    Internal region
 Note    This antibody is expected to recognize reported isoforms 1, 2, 3 and 4 (NP_001005388.2;,NP_001153803.1, NP_001153804.1and NP_055905.2 resp).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NFASC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NFASC antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-NFASC antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 170kDa band observed in Human Lung and Rat Brain lysates (calculated MW of 138kDa according to NP_001005388.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Kirschbaum et al, J Biol Chem.2009 Oct 16;284(42): 28533-42. PMID: 19666467). Recommended concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-NFASC antibody    (0.5ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NFASC antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NFASC. It may not necessarily be applicable to this product.
 NCBI GI #    237858675
 NCBI GeneID    23114
 NCBI Accession #    NP_001005388.2 [Other Products]
 NCBI Related Accession #    NP_001153803.1; NP_001153804.1; NP_055905.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005388.2 [Other Products]
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 UniProt Secondary Accession #    Q149P5; Q5T2F0; Q5T2F1; Q5T2F2; Q5T2F3; Q5T2F4; B2RNN8; B3KQZ1; B5MDP6; B5MDR6; B7ZMD8 [Other Products]
 UniProt Related Accession #    O94856 [Other Products]
 Molecular Weight    142,474 Da
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 NCBI Official Full Name    neurofascin isoform 1
 NCBI Official Synonym Full Names    neurofascin
 NCBI Official Symbol    NFASC [Similar Products]
 NCBI Official Synonym Symbols   
NF; NRCAML
[Similar Products]
 NCBI Protein Information    neurofascin
 UniProt Protein Name    Neurofascin
 Protein Family    Neurofascin
 UniProt Gene Name    NFASC [Similar Products]
 UniProt Synonym Gene Names    KIAA0756 [Similar Products]
 UniProt Entry Name    NFASC_HUMAN
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 NCBI Summary for NFASC    This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
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 UniProt Comments for NFASC    neurofascin: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: focal adhesion; integral to membrane; intracellular; myelin sheath; paranode region of axon; plasma membrane

Molecular Function: protein binding; protein domain specific binding

Biological Process: axon guidance; clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; myelination; paranodal junction assembly; peripheral nervous system development; synapse organization and biogenesis; transmission of nerve impulse
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 Research Articles on NFASC    1. It is a common protein to the central and peripheral nervous system may play a pivotal role in combined demyelination in Combined central and peripheral demyelination.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFASC antibodyPathways associated with anti-NFASC antibody
 Reference Product  PubMed Publications
 NRCAM antibody  >20 publications with NFASC and NRCAM
 CNTNAP1 antibody  >15 publications with NFASC and CNTNAP1
 ANK3 antibody  >12 publications with NFASC and ANK3
 GLDN antibody  >3 publications with NFASC and GLDN
 ANK2 antibody  >2 publications with NFASC and ANK2
 SDCBP antibody  >1 publications with NFASC and SDCBP
 DCX antibody  >1 publications with NFASC and DCX
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
Diseases associated with anti-NFASC antibodyOrgans/Tissues associated with anti-NFASC antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >36 publications with NFASC and Nervous System Diseases
 Immune System Diseases Antibodies  >21 publications with NFASC and Immune System Diseases
 Brain Diseases Antibodies  >16 publications with NFASC and Brain Diseases
 Disease Models, Animal Antibodies  >15 publications with NFASC and Disease Models, Animal
 Nerve Degeneration Antibodies  >5 publications with NFASC and Nerve Degeneration
 Embryo Loss Antibodies  >5 publications with NFASC and Embryo Loss
 Inflammation Antibodies  >5 publications with NFASC and Inflammation
 Congenital Abnormalities Antibodies  >3 publications with NFASC and Congenital Abnormalities
 Nervous System Malformations Antibodies  >3 publications with NFASC and Nervous System Malformations
 Abnormalities, Drug-Induced Antibodies  >1 publications with NFASC and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >123 publications with NFASC and Nerve
 Brain Antibodies  >54 publications with NFASC and Brain
 Embryonic Tissue Antibodies  >13 publications with NFASC and Embryonic Tissue
 Spinal Cord Antibodies  >12 publications with NFASC and Spinal Cord
 Blood Antibodies  >12 publications with NFASC and Blood
 Eye Antibodies  >6 publications with NFASC and Eye
 Muscle Antibodies  >5 publications with NFASC and Muscle
 Kidney Antibodies  >5 publications with NFASC and Kidney
 Ear Antibodies  >1 publications with NFASC and Ear
 Prostate Antibodies  >1 publications with NFASC and Prostate
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