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anti-NGB antibody :: Chicken anti-Canine, Rat Neuroglobin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS614213 anti-NGB antibody
Unit / Price
0.05 mg  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuroglobin (NGB), Polyclonal Antibody

★Popular Item★
 Also Known As   

Neuroglobin

 Product Synonym Names    Anti -Neuroglobin
 Product Gene Name   

anti-NGB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E
 Chromosome Location    Chromosome: 14; NC_000014.8 (77731834..77737655, complement). Location: 14q24.3
 OMIM    605304
 3D Structure    ModBase 3D Structure for Q9NPG2
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 Clonality    Polyclonal
 Isotype    IgY
 Host    Chicken
 Species Reactivity    Canine, Rat
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 Specificity    Recognizes human Neuroglobin at ~17kD.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography
 Form/Format    Supplied as a lyophilized powder from PBS. Reconstitute with 50ul sterile ddH2O.
 Concentration    ~1mg/ml (after reconstitution) (lot specific)
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 Immunogen    Recombinant protein corresponding to 150aa from human Neuroglobin.
 Control No.    C15031782
 Revision No.    061813
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-NGB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NGB antibody

   Neuroglobin, a 151 amino acid reside protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O2 supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression.
 Product Categories/Family for anti-NGB antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-NGB antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Other applications not tested.

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NCBI/Uniprot data below describe general gene information for NGB. It may not necessarily be applicable to this product.
 NCBI GI #    10864065
 NCBI GeneID    58157
 NCBI Accession #    NP_067080.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021257.3 [Other Products]
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 UniProt Primary Accession #    Q9NPG2 [Other Products]
 UniProt Related Accession #    Q9NPG2 [Other Products]
 Molecular Weight    16,933 Da [Similar Products]
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 NCBI Official Full Name    neuroglobin
 NCBI Official Synonym Full Names    neuroglobin
 NCBI Official Symbol    NGB [Similar Products]
 NCBI Official Synonym Symbols   
NGB
[Similar Products]
 NCBI Protein Information    neuroglobin
 UniProt Protein Name    Neuroglobin
 Protein Family    Neuroglobin
 UniProt Gene Name    NGB [Similar Products]
 UniProt Entry Name    NGB_HUMAN
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 NCBI Summary for NGB    This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq]
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 UniProt Comments for NGB    NGB: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Belongs to the globin family.

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: mitochondrion; perikaryon

Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: oxygen transport; apoptosis
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 Research Articles on NGB    1. There is a plausible central role for neuroglobin in the control of apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-NGB antibodyOrgans/Tissues associated with anti-NGB antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >12 publications with NGB and Vascular Diseases
 Neoplasms Antibodies  >5 publications with NGB and Neoplasms
 Wounds and Injuries Antibodies  >3 publications with NGB and Wounds and Injuries
 Lung Diseases Antibodies  >2 publications with NGB and Lung Diseases
 Atherosclerosis Antibodies  >1 publications with NGB and Atherosclerosis
 Infertility, Male Antibodies  >1 publications with NGB and Infertility, Male
 Hepatitis Antibodies  >1 publications with NGB and Hepatitis
 Melanoma Antibodies  >1 publications with NGB and Melanoma
 Urinary Bladder Neoplasms Antibodies  >1 publications with NGB and Urinary Bladder Neoplasms
 Neural Tube Defects Antibodies  >1 publications with NGB and Neural Tube Defects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >83 publications with NGB and Brain
 Eye Antibodies  >8 publications with NGB and Eye
 Lung Antibodies  >5 publications with NGB and Lung
 Embryonic Tissue Antibodies  >1 publications with NGB and Embryonic Tissue
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