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anti-NCS1 antibody :: Rabbit anti-Human, Mouse Neuronal calcium sensor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493938
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuronal calcium sensor 1 (NCS1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Neuronal calcium sensor 1 polyclonal Antibody(NCS1)

 Product Synonym Names    NCS-1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS1; FLUP; FREQ
 Product Gene Name   

anti-NCS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603315
 3D Structure    ModBase 3D Structure for P62166
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Neuronal calcium sensor 1 protein (1-190aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-13165 / sc-13167 / sc-13166 / sc-13037
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NCS1 antibody

   Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
 Applications Tested/Suitable for anti-NCS1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NCS1 antibody    Recommended dilution: WB:1:500-1:2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-NCS1 antibody    All lanes: Neuronal calcium sensor 1 antibody at 10ug/ml
Lane 1:Hela whole cell lysate
Lane 2:rat kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 22,20 kDa
Observed band size: 22 kDa

anti-NCS1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NCS1 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1493938 at dilution 1:100
anti-NCS1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NCS1. It may not necessarily be applicable to this product.
 NCBI GI #    192447423
 NCBI GeneID    23413
 NCBI Accession #    NP_001122298.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001128826.1 [Other Products]
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 UniProt Primary Accession #    P62166 [Other Products]
 UniProt Secondary Accession #    P36610; Q9UK26; E9PAY3 [Other Products]
 UniProt Related Accession #    P62166 [Other Products]
 Molecular Weight    19,728 Da
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 NCBI Official Full Name    neuronal calcium sensor 1 isoform 2
 NCBI Official Synonym Full Names    neuronal calcium sensor 1
 NCBI Official Symbol    NCS1 [Similar Products]
 NCBI Official Synonym Symbols   
FLUP; FREQ
[Similar Products]
 NCBI Protein Information    neuronal calcium sensor 1
 UniProt Protein Name    Neuronal calcium sensor 1
 UniProt Synonym Protein Names   
Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein
 Protein Family    Neuronal calcium sensor
 UniProt Gene Name    NCS1 [Similar Products]
 UniProt Synonym Gene Names    FLUP; FREQ; NCS-1 [Similar Products]
 UniProt Entry Name    NCS1_HUMAN
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 NCBI Summary for NCS1    This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NCS1    FREQ: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: calcium ion binding; magnesium ion binding; protein binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: phosphoinositide-mediated signaling; positive regulation of exocytosis
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 Research Articles on NCS1    1. results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-NCS1 antibodyOrgans/Tissues associated with anti-NCS1 antibody
 Disease Name  Pubmed Publications
 Glucose Intolerance Antibodies  >1 publications with NCS1 and Glucose Intolerance
 Neoplasm Invasiveness Antibodies  >1 publications with NCS1 and Neoplasm Invasiveness
 Learning Disorders Antibodies  >1 publications with NCS1 and Learning Disorders
 Hypertrophy Antibodies  >1 publications with NCS1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NCS1 and Brain
 Nerve Antibodies  >2 publications with NCS1 and Nerve
 Heart Antibodies  >2 publications with NCS1 and Heart
 Blood Antibodies  >1 publications with NCS1 and Blood
 Skin Antibodies  >1 publications with NCS1 and Skin
 Kidney Antibodies  >1 publications with NCS1 and Kidney
 Eye Antibodies  >1 publications with NCS1 and Eye
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