AAA59945.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
10,851 Da
NCBI Official Full Name
neuropeptide Y, partial
NCBI Official Synonym Full Names
neuropeptide Y
NCBI Official Synonym Symbols
NCBI Protein Information
pro-neuropeptide Y; prepro-neuropeptide Y
UniProt Protein Name
Pro-neuropeptide Y
UniProt Synonym Protein Names
Neuropeptide tyrosine
UniProt Synonym Gene Names
UniProt Entry Name
NPY_HUMAN
NCBI Summary for NPY
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
UniProt Comments for NPY
NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family.
Protein type: Secreted, signal peptide; Secreted; Hormone
Chromosomal Location of Human Ortholog: 7p15.1
Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region
Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding
Biological Process: blood circulation; behavior; adult feeding behavior; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell proliferation; neuropeptide signaling pathway; positive regulation of appetite; regulation of blood pressure; calcium ion transport; digestion; regulation of appetite; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development
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Products associated with anti-NPY antibody
Pathways associated with anti-NPY antibody
Diseases associated with anti-NPY antibody
Organs/Tissues associated with anti-NPY antibody
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