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anti-NPY5R antibody :: Goat Neuropeptide Y receptor Y5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420766
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuropeptide Y receptor Y5 (NPY5R), Polyclonal Antibody

 Also Known As   

Goat anti-Neuropeptide Y receptor Y5 Antibody

 Product Synonym Names    neuropeptide Y receptor Y5; HGNC: 7958; NPY5R; NPYR5; neuropeptide Y receptor Y5 antibody; HGNC: 7958 antibody; NPY5R antibody; NPYR5 antibody; Neuropeptide Y receptor Y5; Neuropeptide Y receptor Y5
 Product Gene Name   

anti-NPY5R antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Neuropeptide Y receptor Y5 (MBS420766)
Biotin Conjugated Antibody: Neuropeptide Y receptor Y5 (MBS423675)
 Antibody/Peptide Pairs    Neuropeptide Y receptor Y5 peptide (MBS425920) is used for blocking the activity of Neuropeptide Y receptor Y5 antibody (MBS420766)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    GLSNKENRLE EN
 OMIM    602001
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-GLSNKENRLEEN, from the internal region of the protein sequence according to NP_006165.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NPY5R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NPY5R antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-NPY5R antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Intestine shows staining of ganglion cells. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 50kDa band observed in Human Brain, Breast and Duodenum lysates (calculated MW of 50.7kDa according to NP_006165.1). Recommended concentration: 0.3-1ug/ml.
Immunoprecipitation: Customer feedback showed specific results when this product was used in IP.
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 Western Blot (WB) of anti-NPY5R antibody    (0.3ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NPY5R antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NPY5R antibody    (3.8ug/ml) staining of paraffin embedded Human Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-NPY5R antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NPY5R. It may not necessarily be applicable to this product.
 NCBI GI #    5453796
 NCBI GeneID    4889
 NCBI Accession #    NP_006165.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006174.3 [Other Products]
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 UniProt Secondary Accession #    Q6GTR7; Q92916 [Other Products]
 UniProt Related Accession #    Q15761 [Other Products]
 Molecular Weight    50,727 Da
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 NCBI Official Full Name    neuropeptide Y receptor type 5
 NCBI Official Synonym Full Names    neuropeptide Y receptor Y5
 NCBI Official Symbol    NPY5R [Similar Products]
 NCBI Official Synonym Symbols   
NPYR5; NPY5-R; NPYY5-R
[Similar Products]
 NCBI Protein Information    neuropeptide Y receptor type 5
 UniProt Protein Name    Neuropeptide Y receptor type 5
 UniProt Synonym Protein Names   
NPY-Y5 receptor; NPYY5-R; Y5 receptor
 Protein Family    Neuropeptide Y receptor
 UniProt Gene Name    NPY5R [Similar Products]
 UniProt Synonym Gene Names    NPYR5; NPY5-R; NPYY5-R; Y5 receptor [Similar Products]
 UniProt Entry Name    NPY5R_HUMAN
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 NCBI Summary for NPY5R    The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
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 UniProt Comments for NPY5R    NPY5R: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity

Biological Process: cell surface receptor linked signal transduction; eating behavior; feeding behavior; G-protein coupled receptor protein signaling pathway; generation of ovulation cycle rhythm; negative regulation of apoptosis; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; neuropeptide signaling pathway; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation; synaptic transmission
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 Research Articles on NPY5R    1. NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NPY5R antibodyDiseases associated with anti-NPY5R antibody
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Disease Name  Pubmed Publications
 Obesity Antibodies  >12 publications with NPY5R and Obesity
 Nervous System Diseases Antibodies  >6 publications with NPY5R and Nervous System Diseases
 Weight Loss Antibodies  >4 publications with NPY5R and Weight Loss
 Brain Diseases Antibodies  >4 publications with NPY5R and Brain Diseases
 Hypertension Antibodies  >2 publications with NPY5R and Hypertension
 Disease Models, Animal Antibodies  >2 publications with NPY5R and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >2 publications with NPY5R and Neurobehavioral Manifestations
 Seizures Antibodies  >2 publications with NPY5R and Seizures
 Inflammation Antibodies  >2 publications with NPY5R and Inflammation
 Kidney Diseases Antibodies  >1 publications with NPY5R and Kidney Diseases
Organs/Tissues associated with anti-NPY5R antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with NPY5R and Brain
 Kidney Antibodies  >2 publications with NPY5R and Kidney
 Testis Antibodies  >1 publications with NPY5R and Testis
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