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anti-NPY antibody :: Rabbit Neuropeptide Y Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551066
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuropeptide Y (NPY), Polyclonal Antibody

 Also Known As   

Rabbit anti Neuropeptide Y Polyclonal

 Product Synonym Names    Rabbit anti Neuropeptide Y Polyclonal purified; npy; neuropeptide y; polyclonal
 Product Gene Name   

anti-NPY antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162640
 3D Structure    ModBase 3D Structure for P01303
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Rabbit
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 Purity/Purification    Serum IgG fraction was purified by Protein G affinity chromatography.
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal Neuropeptide Y (NPY) antibody was produced from sera of mice immunized with synthetic protein containing Neuropeptide Y antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
 Other Notes    Small volumes of anti-NPY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NPY antibody    Polyclonal
 Applications Tested/Suitable for anti-NPY antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-NPY antibody    ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemical analysis of FFPE rat brain cancer tissue expressing Neuropeptide Y.
Immunohistochemical analysis of FFPE rabbit rabbit intervertebral disc cartilage expressing Neuropeptide Y.
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 Immunohistochemistry of anti-NPY antibody    anti-NPY antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for NPY. It may not necessarily be applicable to this product.
 NCBI GI #    4505449
 NCBI GeneID    4852
 NCBI Accession #    NP_000896.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000905.3 [Other Products]
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 UniProt Primary Accession #    P01303 [Other Products]
 UniProt Related Accession #    P01303 [Other Products]
 Molecular Weight    10,851 Da
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 NCBI Official Full Name    pro-neuropeptide Y preproprotein
 UniProt Protein Name    Pro-neuropeptide Y
 UniProt Synonym Protein Names   
Neuropeptide tyrosine
 Protein Family    Neuropeptide
 UniProt Gene Name    NPY [Similar Products]
 UniProt Synonym Gene Names    NPY; CPON [Similar Products]
 UniProt Entry Name    NPY_HUMAN
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 NCBI Summary for NPY    This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
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 UniProt Comments for NPY    NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 7p15.1

Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region

Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding

Biological Process: blood circulation; behavior; adult feeding behavior; cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; neuropeptide signaling pathway; calcium ion transport; regulation of blood pressure; positive regulation of appetite; digestion; regulation of appetite; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development
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Product References and Citations for anti-NPY antibody

   identification of Neuropeptide Y-like conopeptides from the venom of conus betulinus .Acta Biochim Biophys Sin, Jun 2010; 10.1093/abbs/gmq042.
Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via y1 receptors .Endocrinology, Jun 2010; 151: 2736 - 2746.
the central and basolateral amygdala are critical sites of Neuropeptide Y/y2 receptor-mediated regulation of anxiety and depression .J. Neurosci., May 2010; 30: 6282 - 6290.
estrogen modulates the contribution of Neuropeptide Y to baseline hindlimb blood flow control in female sprague-dawley rats .Am J Physiol Regulatory Integrative Comp Physiol, May 2010; 298: R1351 - R1357.
kisspeptin cells in the ewe brain respond to leptin and communicate with Neuropeptide Y and proopiomelanocortin cells .Endocrinology, May 2010; 151: 2233 - 2243.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPY antibodyPathways associated with anti-NPY antibody
 Reference Product  PubMed Publications
 MC4R antibody  >38 publications with NPY and MC4R
 NPY1R antibody  >34 publications with NPY and NPY1R
 NPFF antibody  >12 publications with NPY and NPFF
 NPY2R antibody  >9 publications with NPY and NPY2R
 NPY5R antibody  >7 publications with NPY and NPY5R
 GHRL antibody  >4 publications with NPY and GHRL
 PPYR1 antibody  >1 publications with NPY and PPYR1
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-NPY antibodyOrgans/Tissues associated with anti-NPY antibody
 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with NPY and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Obesity Antibodies  >665 publications with NPY and Obesity
 Neoplasms Antibodies  >292 publications with NPY and Neoplasms
 Metabolic Diseases Antibodies  >286 publications with NPY and Metabolic Diseases
 Mental Disorders Antibodies  >285 publications with NPY and Mental Disorders
 Hyperphagia Antibodies  >263 publications with NPY and Hyperphagia
 Weight Gain Antibodies  >255 publications with NPY and Weight Gain
 Hypertension Antibodies  >229 publications with NPY and Hypertension
 Anorexia Antibodies  >183 publications with NPY and Anorexia
 Epilepsy Antibodies  >166 publications with NPY and Epilepsy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3718 publications with NPY and Brain
 Nerve Antibodies  >2057 publications with NPY and Nerve
 Muscle Antibodies  >811 publications with NPY and Muscle
 Pancreas Antibodies  >180 publications with NPY and Pancreas
 Uterus Antibodies  >58 publications with NPY and Uterus
 Prostate Antibodies  >54 publications with NPY and Prostate
 Placenta Antibodies  >18 publications with NPY and Placenta
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