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anti-NTF3 antibody :: Goat Neurotrophin 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421732 anti-NTF3 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurotrophin 3 (NTF3), Polyclonal Antibody

 Also Known As   

Goat anti-Neurotrophin 3 Antibody

 Product Synonym Names    NTF3; neurotrophin 3; HDNF; MGC129711; NGF-2; NGF2; NT3; NTF3 antibody; neurotrophin 3 antibody; HDNF antibody; MGC129711 antibody; NGF-2 antibody; NGF2 antibody; NT3 antibody; Neurotrophin 3; Neurotrophin 3
 Product Gene Name   

anti-NTF3 antibody

[Similar Products]
 Antibody/Peptide Pairs    Neurotrophin 3 peptide (MBS426804) is used for blocking the activity of Neurotrophin 3 antibody (MBS421732)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TSRRKRYAEH KSH
 OMIM    162660
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TSRRKRYAEHKSH, from the internal region of the protein sequence according to NP_001096124.1; NP_002518.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both isoforms (NP_001096124.1; NP_002518.1)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NTF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NTF3 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-NTF3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum and Hippocampus) lysates gave no specific signal but low background (at antibody concentration up to 2ug/ml).
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NCBI/Uniprot data below describe general gene information for NTF3. It may not necessarily be applicable to this product.
 NCBI GI #    156630995
 NCBI GeneID    4908
 NCBI Accession #    NP_001096124.1 [Other Products]
 NCBI Related Accession #    NP_002518.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001102654.1 [Other Products]
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 UniProt Secondary Accession #    Q6FH50; B7Z1T5 [Other Products]
 UniProt Related Accession #    P20783 [Other Products]
 Molecular Weight    30,800 Da
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 NCBI Official Full Name    neurotrophin-3 isoform 1 preproprotein
 NCBI Official Synonym Full Names    neurotrophin 3
 NCBI Official Symbol    NTF3 [Similar Products]
 NCBI Official Synonym Symbols   
NT3; HDNF; NGF2; NT-3; NGF-2
[Similar Products]
 NCBI Protein Information    neurotrophin-3
 UniProt Protein Name    Neurotrophin-3
 UniProt Synonym Protein Names   
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
 Protein Family    Neurotrophin
 UniProt Gene Name    NTF3 [Similar Products]
 UniProt Synonym Gene Names    NT-3; NGF-2 [Similar Products]
 UniProt Entry Name    NTF3_HUMAN
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 NCBI Summary for NTF3    The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NTF3    NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: chemoattractant activity; growth factor activity; nerve growth factor binding; neurotrophin p75 receptor binding; protein binding; receptor binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cell-cell signaling; induction of positive chemotaxis; myelination; negative regulation of neuron apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; neurite morphogenesis; positive chemotaxis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of glial cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; regulation of apoptosis; regulation of neuron differentiation; regulation of synaptic transmission; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on NTF3    1. Survival, differentiation, and neuroprotective mechanisms of human stem cells complexed with neurotrophin-3-releasing pharmacologically active microcarriers in an ex vivo model of Parkinson's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NTF3 antibodyDiseases associated with anti-NTF3 antibody
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Trk Receptor Signaling Mediated By The MAPK Pathway antibodies  Trk Receptor Signaling Mediated By The MAPK Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with NTF3 and Nervous System Diseases
 Hearing Loss Antibodies  >4 publications with NTF3 and Hearing Loss
 Memory Disorders Antibodies  >2 publications with NTF3 and Memory Disorders
 Learning Disorders Antibodies  >2 publications with NTF3 and Learning Disorders
 Chromosome Aberrations Antibodies  >2 publications with NTF3 and Chromosome Aberrations
 Schizophrenia Antibodies  >2 publications with NTF3 and Schizophrenia
 Hypertension Antibodies  >1 publications with NTF3 and Hypertension
 Disease Models, Animal Antibodies  >1 publications with NTF3 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with NTF3 and Inflammation
 Nerve Degeneration Antibodies  >1 publications with NTF3 and Nerve Degeneration
Organs/Tissues associated with anti-NTF3 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with NTF3 and Brain
 Testis Antibodies  >4 publications with NTF3 and Testis
 Embryonic Tissue Antibodies  >3 publications with NTF3 and Embryonic Tissue
 Eye Antibodies  >2 publications with NTF3 and Eye
 Ovary Antibodies  >1 publications with NTF3 and Ovary
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