NP_004549.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
neurturin preproprotein
NCBI Official Synonym Full Names
neurturin
NCBI Official Synonym Symbols
NCBI Protein Information
neurturin
UniProt Protein Name
Neurturin
UniProt Entry Name
NRTN_HUMAN
NCBI Summary for NRTN
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]
UniProt Comments for NRTN
NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: axon; extracellular region; intracellular
Molecular Function: growth factor activity; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: MAPKKK cascade; nerve development; nervous system development; neural crest cell migration; neurite development; positive regulation of GTPase activity; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Hirschsprung Disease, Susceptibility To, 1
Research Articles on NRTN
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-NRTN antibody
Pathways associated with anti-NRTN antibody
Diseases associated with anti-NRTN antibody
Organs/Tissues associated with anti-NRTN antibody
|