NP_001272762.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,519 Da
NCBI Official Full Name
NADPH oxidase 4 isoform 2
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Official Synonym Symbols
NCBI Protein Information
NADPH oxidase 4; KOX-1; kidney oxidase-1; renal NAD(P)H-oxidase; superoxide-generating NADPH oxidase 4; kidney superoxide-producing NADPH oxidase
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
UniProt Synonym Gene Names
UniProt Entry Name
NOX4_MOUSE
UniProt Comments for NOX4
NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.6.3.-; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Cell cycle regulation; Nucleolus
Cellular Component: focal adhesion; membrane; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; apical plasma membrane; plasma membrane; integral to membrane; stress fiber; cell junction; NADPH oxidase complex
Molecular Function: NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor; oxidoreductase activity
Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of stress fiber formation; cell morphogenesis; superoxide metabolic process; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; superoxide release; cardiac muscle cell differentiation; bone resorption
Research Articles on NOX4
Precautions
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Pathways associated with anti-NOX4 antibody
Diseases associated with anti-NOX4 antibody
Organs/Tissues associated with anti-NOX4 antibody
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