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anti-NOS3 antibody :: Rabbit Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS316207 anti-NOS3 antibody
Unit / Price
0.1 mL  /  $420 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11) (NOS3), Polyclonal Antibody

 Also Known As   

Rabbit anti eNOS

 Product Synonym Names    Rabbit Antibody to Human Endothelial Nitric Oxide Synthase (eNOS)
 Product Gene Name   

anti-NOS3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (150688144..150711687). Location: 7q36
 OMIM    163729
 3D Structure    ModBase 3D Structure for P29474
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11)
Recognizes Human Endothelial Nitric Oxide Synthase (eNOS). Specific for the amino terminal of eNOS. It recognizes the non-myrisylated form best, but does cross-react ~50% with the myristylated form
 Form/Format    Neat, Lyophilized.
Reconstitute with 0.1ml PBS containing 10mg/ml BSA or with additional buffer for more dilute antibody.
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 Immunogen    eNOS (2-11 Cys^12) covalently attached to a carrier protein.
 Buffer    Not applicable.
 Preservative    No
 Lyophilized    Yes
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 Preparation and Storage    Store lyophilized product at 2 to 8 degree C (preferably in a dessicator). After reconstitution, aliquot and store at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NOS3 antibody    Polyclonal Antibodies for Neuroscience
NCBI/Uniprot data below describe general gene information for NOS3. It may not necessarily be applicable to this product.
 NCBI GI #    266648
 NCBI GeneID    4846
 NCBI Accession #    P29474.3 [Other Products]
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 UniProt Primary Accession #    P29474 [Other Products]
 UniProt Secondary Accession #    Q13662; Q14251; Q14434; Q548C1; Q6GSL5; Q9UDC6; A8KA63; B2RCQ1 [Other Products]
 UniProt Related Accession #    O14937; P29474; Q96J98; Q96P37 [Other Products]
 Molecular Weight    133,289 Da [Similar Products]
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 NCBI Official Full Name    Nitric oxide synthase, endothelial
 NCBI Official Synonym Full Names    nitric oxide synthase 3 (endothelial cell)
 NCBI Official Symbol    NOS3 [Similar Products]
 NCBI Official Synonym Symbols   
eNOS; ECNOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, endothelial; cNOS; EC-NOS; NOSIII; NOS type III; endothelial NOS; constitutive NOS; OTTHUMP00000212826; OTTHUMP00000213183; OTTHUMP00000213184; OTTHUMP00000213185
 UniProt Protein Name    Nitric oxide synthase, endothelial
 UniProt Synonym Protein Names   
Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III
 Protein Family    Nitric oxide synthase
 UniProt Gene Name    NOS3 [Similar Products]
 UniProt Entry Name    NOS3_HUMAN
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 NCBI Summary for NOS3    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for NOS3    Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Catalytic activity: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.

Cofactor: Heme group.Binds 1 FAD.Binds 1 FMN.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.

Enzyme regulation: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Ref.19 Ref.20

Subunit structure: Homodimer. Interacts with NOSIP and NOSTRIN. Ref.19 Ref.20

Subcellular location: Cell membrane. Membrane › caveola. Cytoplasm › cytoskeleton. Golgi apparatus. Note: Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. Ref.19 Ref.20 Ref.21 Ref.22

Tissue specificity: Platelets, placenta, liver and kidney. Ref.18

Polymorphism: Variation in NOS3 seem to be associated with susceptibility to coronary spasm.

Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.
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 Research Articles on NOS3    1. Data show that that eNOS4a/b polymorphism and plasma NOx levels were predictive factors for developing bone metastasis and high stage disease after adjustment for age and BMI.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOS3 antibodyPathways associated with anti-NOS3 antibody
 Reference Product  PubMed Publications
 AKT1 antibody  >106 publications with NOS3 and AKT1
 CAV1 antibody  >51 publications with NOS3 and CAV1
 BDKRB2 antibody  >26 publications with NOS3 and BDKRB2
 SP1 antibody  >19 publications with NOS3 and SP1
 AGTR1 antibody  >14 publications with NOS3 and AGTR1
 NOSIP antibody  >5 publications with NOS3 and NOSIP
 BDNF antibody  >5 publications with NOS3 and BDNF
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Nitric Oxide Pathway antibodies  Metabolism Of Nitric Oxide Pathway Diagram
Diseases associated with anti-NOS3 antibodyOrgans/Tissues associated with anti-NOS3 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1602 publications with NOS3 and Cardiovascular Diseases
 Hypertension Antibodies  >823 publications with NOS3 and Hypertension
 Myocardial Ischemia Antibodies  >446 publications with NOS3 and Myocardial Ischemia
 Inflammation Antibodies  >365 publications with NOS3 and Inflammation
 Atherosclerosis Antibodies  >352 publications with NOS3 and Atherosclerosis
 Coronary Artery Disease Antibodies  >301 publications with NOS3 and Coronary Artery Disease
 Arteriosclerosis Antibodies  >280 publications with NOS3 and Arteriosclerosis
 Kidney Diseases Antibodies  >215 publications with NOS3 and Kidney Diseases
 Lung Diseases Antibodies  >209 publications with NOS3 and Lung Diseases
 Reperfusion Injury Antibodies  >196 publications with NOS3 and Reperfusion Injury
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2840 publications with NOS3 and Vascular
 Blood Antibodies  >2078 publications with NOS3 and Blood
 Heart Antibodies  >850 publications with NOS3 and Heart
 Kidney Antibodies  >402 publications with NOS3 and Kidney
 Brain Antibodies  >345 publications with NOS3 and Brain
 Lung Antibodies  >297 publications with NOS3 and Lung
 Liver Antibodies  >191 publications with NOS3 and Liver
 Embryonic Tissue Antibodies  >186 publications with NOS3 and Embryonic Tissue
 Bone Antibodies  >101 publications with NOS3 and Bone
 Skin Antibodies  >71 publications with NOS3 and Skin
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