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anti-RTN4 antibody :: Rabbit NogoA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151432
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NogoA (RTN4), Polyclonal Antibody

 Also Known As   

NogoA Antibody

 Product Synonym Names    NogoA; ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545; KIAA0886; My043; SP1507; Reticulon-4; Foocen; Nogo protein; reticulon 4
 Product Gene Name   

anti-RTN4 antibody

[Similar Products]
 Antibody/Peptide Pairs    NogoA peptide (MBS152822) is used for blocking the activity of NogoA antibody (MBS151432)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604475
 3D Structure    ModBase 3D Structure for Q9NQC3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least five isoforms of Nogo are known to exist; this antibody is specific for NogoA.
 Purity/Purification    NogoA Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    NogoA antibody was raised against a 23 amino acid synthetic peptide from near the amino terminus of human NogoA.
 Buffer    NogoA Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    NogoA antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-RTN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RTN4 antibody

   NogoA Antibody: NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS; blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
 Applications Tested/Suitable for anti-RTN4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-RTN4 antibody    NogoA antibody can be used for detection of NogoA by Western blot at 0.5 - 1 mug/mL. Despite its predicted molecular weight, NogoA typically migrates at 180 kDa in an SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-RTN4 antibody    Western blot analysis of NogoA in mouse brain tissue lysate with NogoA antibody at (A) 0.5 and (B) 1 μg/mL.
anti-RTN4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RTN4 antibody    Immunohistochemistry of NogoA in mouse brain tissue with NogoA antibody at 2.5 μg/mL.
anti-RTN4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RTN4 antibody    Immunofluorescence of NogoA in Mouse Brain cells with NogoA antibody at 20 μg/mL.
anti-RTN4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RTN4. It may not necessarily be applicable to this product.
 NCBI GI #    24431935
 NCBI GeneID    57142
 NCBI Accession #    NP_065393 [Other Products]
 NCBI GenBank Nucleotide #    NM_020532.4 [Other Products]
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 UniProt Primary Accession #    Q9NQC3 [Other Products]
 UniProt Secondary Accession #    O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9UQ42; Q9Y293 [Other Products]
 UniProt Related Accession #    Q9NQC3 [Other Products]
 Molecular Weight    108,450 Da
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 NCBI Official Full Name    reticulon-4 isoform A
 NCBI Official Synonym Full Names    reticulon 4
 NCBI Official Symbol    RTN4 [Similar Products]
 NCBI Official Synonym Symbols   
ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545
[Similar Products]
 NCBI Protein Information    reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog
 UniProt Protein Name    Reticulon-4
 UniProt Synonym Protein Names   
Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5
 Protein Family    Reticulon
 UniProt Gene Name    RTN4 [Similar Products]
 UniProt Synonym Gene Names    KIAA0886; NOGO; Nogo protein; NSP [Similar Products]
 UniProt Entry Name    RTN4_HUMAN
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 NCBI Summary for RTN4    This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RTN4    Nogo: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Endoplasmic reticulum; Membrane protein, multi-pass; Inhibitor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 2p16.3

Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular

Molecular Function: protein binding

Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; angiogenesis; negative regulation of axon extension; negative regulation of cell growth; regulation of axonogenesis; regulation of cell migration
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 Research Articles on RTN4    1. the present study found that Nogo-A depletion was capable of inhibiting HCC SMMC-7721 cell proliferation by promoting G2/M cell cycle arrest and apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RTN4 antibodyDiseases associated with anti-RTN4 antibody
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram
 P75NTR Regulates Axonogenesis Pathway antibodies  P75NTR Regulates Axonogenesis Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with RTN4 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with RTN4 and Brain Diseases
 Cardiovascular Diseases Antibodies  >7 publications with RTN4 and Cardiovascular Diseases
 Schizophrenia Antibodies  >6 publications with RTN4 and Schizophrenia
 Disease Models, Animal Antibodies  >4 publications with RTN4 and Disease Models, Animal
 Heart Diseases Antibodies  >3 publications with RTN4 and Heart Diseases
 Movement Disorders Antibodies  >2 publications with RTN4 and Movement Disorders
 Hypertension Antibodies  >2 publications with RTN4 and Hypertension
 Inflammation Antibodies  >1 publications with RTN4 and Inflammation
 Liver Diseases Antibodies  >1 publications with RTN4 and Liver Diseases
Organs/Tissues associated with anti-RTN4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with RTN4 and Brain
 Nerve Antibodies  >26 publications with RTN4 and Nerve
 Vascular Antibodies  >12 publications with RTN4 and Vascular
 Muscle Antibodies  >10 publications with RTN4 and Muscle
 Blood Antibodies  >5 publications with RTN4 and Blood
 Heart Antibodies  >4 publications with RTN4 and Heart
 Liver Antibodies  >3 publications with RTN4 and Liver
 Eye Antibodies  >2 publications with RTN4 and Eye
 Embryonic Tissue Antibodies  >2 publications with RTN4 and Embryonic Tissue
 Kidney Antibodies  >2 publications with RTN4 and Kidney
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