AAA36377.2
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NOTCH 2
NCBI Official Synonym Full Names
notch 2
NCBI Protein Information
neurogenic locus notch homolog protein 2
UniProt Protein Name
Neurogenic locus notch homolog protein 2
UniProt Synonym Gene Names
UniProt Entry Name
NOTC2_HUMAN
NCBI Summary for NOTCH2
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for NOTCH2
Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p13-p11
Cellular Component: cell surface; cilium; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function: calcium ion binding; protein binding; receptor activity
Biological Process: apoptosis; bone remodeling; cell cycle arrest; cell fate determination; cell growth; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; gene expression; hemopoiesis; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; intracellular receptor-mediated signaling pathway; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; multicellular organismal development; myeloid dendritic cell differentiation; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch receptor processing; Notch signaling pathway; organ morphogenesis; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of Ras protein signal transduction; regulation of developmental process; regulation of transcription, DNA-dependent; stem cell maintenance; tissue regeneration; transcription initiation from RNA polymerase II promoter
Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome
Research Articles on NOTCH2
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Products associated with anti-NOTCH2 antibody
Pathways associated with anti-NOTCH2 antibody
Diseases associated with anti-NOTCH2 antibody
Organs/Tissues associated with anti-NOTCH2 antibody
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