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anti-Nrf2 antibody :: Rabbit Nrf2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9405834
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nrf2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Nrf2 Polyclonal Antibody

 Product Synonym Names    NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2
 Product Gene Name   

anti-Nrf2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600492
 3D Structure    ModBase 3D Structure for Q16236
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Nrf2 Polyclonal Antibody detects endogenous levels of Nrf2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from the C-terminal region of human Nrf2.
 Target Name    Nrf2
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-Nrf2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Nrf2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-Nrf2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-Nrf2 antibody    Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
Immunofluorescence: 1:200 - 1:1000
ELISA: 1:40000
Not yet tested in other applications.
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 Western Blot (WB) of anti-Nrf2 antibody    Western Blot analysis of HuvEc cells using Nrf2 Polyclonal Antibody
anti-Nrf2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-Nrf2 antibody    Western Blot analysis of KB HELA cells using Nrf2 Polyclonal Antibody
anti-Nrf2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Nrf2. It may not necessarily be applicable to this product.
 NCBI GI #    224028257
 NCBI GeneID    4780
 NCBI Accession #    NP_001138884.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145412.3 [Other Products]
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 UniProt Primary Accession #    Q16236 [Other Products]
 UniProt Secondary Accession #    Q53RW6; Q59HH2; Q96F71; B2RBU2; B4E338; E9PGJ7 [Other Products]
 UniProt Related Accession #    Q16236 [Other Products]
 Molecular Weight    68kD
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 NCBI Official Full Name    nuclear factor erythroid 2-related factor 2 isoform 2
 NCBI Official Synonym Full Names    nuclear factor, erythroid 2-like 2
 NCBI Official Symbol    NFE2L2 [Similar Products]
 NCBI Official Synonym Symbols   
NRF2; HEBP1
[Similar Products]
 NCBI Protein Information    nuclear factor erythroid 2-related factor 2
 UniProt Protein Name    Nuclear factor erythroid 2-related factor 2
 UniProt Synonym Protein Names   
HEBP1; Nuclear factor, erythroid derived 2, like 2
 UniProt Gene Name    NFE2L2 [Similar Products]
 UniProt Synonym Gene Names    NRF2; NF-E2-related factor 2; NFE2-related factor 2 [Similar Products]
 UniProt Entry Name    NF2L2_HUMAN
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 NCBI Summary for Nrf2    This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Nrf2    NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; chromatin; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on Nrf2    1. Lower expression of miR-340 is involved in the development of cisplatin resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Nrf2 antibodyPathways associated with anti-Nrf2 antibody
 Reference Product  PubMed Publications
 HMOX1 antibody  >1174 publications with Nrf2 and HMOX1
 KEAP1 antibody  >826 publications with Nrf2 and KEAP1
 JUN antibody  >475 publications with Nrf2 and JUN
 CUL3 antibody  >68 publications with Nrf2 and CUL3
 MAFK antibody  >30 publications with Nrf2 and MAFK
 MAFG antibody  >25 publications with Nrf2 and MAFG
 GSTA2 antibody  >23 publications with Nrf2 and GSTA2
 MAFF antibody  >4 publications with Nrf2 and MAFF
 UBC antibody  >4 publications with Nrf2 and UBC
 EIF2AK3 antibody  >1 publications with Nrf2 and EIF2AK3
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
Diseases associated with anti-Nrf2 antibodyOrgans/Tissues associated with anti-Nrf2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >678 publications with Nrf2 and Inflammation
 Nervous System Diseases Antibodies  >381 publications with Nrf2 and Nervous System Diseases
 Necrosis Antibodies  >309 publications with Nrf2 and Necrosis
 Liver Diseases Antibodies  >299 publications with Nrf2 and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >131 publications with Nrf2 and Drug-Induced Liver Injury
 Kidney Diseases Antibodies  >130 publications with Nrf2 and Kidney Diseases
 Fibrosis Antibodies  >123 publications with Nrf2 and Fibrosis
 Liver Neoplasms Antibodies  >117 publications with Nrf2 and Liver Neoplasms
 Gastrointestinal Diseases Antibodies  >112 publications with Nrf2 and Gastrointestinal Diseases
 Heart Diseases Antibodies  >110 publications with Nrf2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >659 publications with Nrf2 and Liver
 Blood Antibodies  >538 publications with Nrf2 and Blood
 Lung Antibodies  >443 publications with Nrf2 and Lung
 Brain Antibodies  >397 publications with Nrf2 and Brain
 Vascular Antibodies  >296 publications with Nrf2 and Vascular
 Muscle Antibodies  >234 publications with Nrf2 and Muscle
 Kidney Antibodies  >231 publications with Nrf2 and Kidney
 Heart Antibodies  >214 publications with Nrf2 and Heart
 Skin Antibodies  >131 publications with Nrf2 and Skin
 Nerve Antibodies  >91 publications with Nrf2 and Nerve
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