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anti-NRF1 antibody :: Rabbit anti-Mouse Nuclear Respiratory Factor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622365 anti-NRF1 antibody
Unit / Price
0.05 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear Respiratory Factor 1 (NRF1), Polyclonal Antibody

 Also Known As   

Nuclear Respiratory Factor 1 (NRF1, NRF-1, Alpha-PAL, EWG)

 Product Synonym Names    Anti -Nuclear Respiratory Factor 1 (NRF1, NRF-1, Alpha-PAL, EWG)
 Product Gene Name   

anti-NRF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (129251555..129396922). Location: 7q32
 OMIM    600879
 3D Structure    ModBase 3D Structure for Q16656
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    Recognizes Mouse Nuclear Respiratory Factor 1 (NRF1). Species Crossreactivity: Mouse.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
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 Immunogen    Synthetic peptide, KLH-conjugated. Epitope: Purified recombinant mouse NRF1 protein corresponding to aa 1- 534 of the native protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-NRF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NRF1 antibody    Antibodies; Abs to Nuclear Proteins
 Applications Tested/Suitable for anti-NRF1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NRF1 antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 2-5ug/ml
ELISA: 1:3000-1:10,000
Western Blot: 1:500-1:2000
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NCBI/Uniprot data below describe general gene information for NRF1. It may not necessarily be applicable to this product.
 NCBI GI #    93141037
 NCBI GeneID    4899
 NCBI Accession #    NP_005002.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005011.3 [Other Products]
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 UniProt Primary Accession #    Q16656 [Other Products]
 UniProt Secondary Accession #    Q15305 [Other Products]
 UniProt Related Accession #    Q16656; Q96AN2 [Other Products]
 Molecular Weight    53,541 Da [Similar Products]
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 NCBI Official Full Name    nuclear respiratory factor 1
 NCBI Official Synonym Full Names    nuclear respiratory factor 1
 NCBI Official Symbol    NRF1 [Similar Products]
 NCBI Official Synonym Symbols   
ALPHA-PAL
[Similar Products]
 NCBI Protein Information    nuclear respiratory factor 1; NRF-1; OTTHUMP00000184912; OTTHUMP00000184913; OTTHUMP00000184914; alpha palindromic-binding protein
 UniProt Protein Name    Nuclear respiratory factor 1
 UniProt Synonym Protein Names   
Alpha palindromic-binding protein
 Protein Family    Nuclear respiratory factor
 UniProt Gene Name    NRF1 [Similar Products]
 UniProt Entry Name    NRF1_HUMAN
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 NCBI Summary for NRF1    This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq]
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 UniProt Comments for NRF1    NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: nucleoplasm; cytoplasm

Biological Process: mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; organelle organization and biogenesis; response to lipopolysaccharide; cellular lipid metabolic process; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; response to folic acid; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus
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 Research Articles on NRF1    1. Data demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (rs1882095) increased the risk of type 2 diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NRF1 antibodyPathways associated with anti-NRF1 antibody
 Reference Product  PubMed Publications
 TFAM antibody  >42 publications with NRF1 and TFAM
 PPARGC1A antibody  >25 publications with NRF1 and PPARGC1A
 MAFF antibody  >4 publications with NRF1 and MAFF
 Products by Pathway  Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
Diseases associated with anti-NRF1 antibodyOrgans/Tissues associated with anti-NRF1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with NRF1 and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >13 publications with NRF1 and Diabetes Mellitus, Type 2
 Insulin Resistance Antibodies  >13 publications with NRF1 and Insulin Resistance
 Liver Diseases Antibodies  >12 publications with NRF1 and Liver Diseases
 Necrosis Antibodies  >9 publications with NRF1 and Necrosis
 Skin Diseases Antibodies  >8 publications with NRF1 and Skin Diseases
 Inflammation Antibodies  >7 publications with NRF1 and Inflammation
 Central Nervous System Diseases Antibodies  >7 publications with NRF1 and Central Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5 publications with NRF1 and Cardiovascular Diseases
 Fatty Liver Antibodies  >5 publications with NRF1 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with NRF1 and Liver
 Heart Antibodies  >15 publications with NRF1 and Heart
 Blood Antibodies  >14 publications with NRF1 and Blood
 Brain Antibodies  >13 publications with NRF1 and Brain
 Lung Antibodies  >9 publications with NRF1 and Lung
 Embryonic Tissue Antibodies  >8 publications with NRF1 and Embryonic Tissue
 Kidney Antibodies  >7 publications with NRF1 and Kidney
 Skin Antibodies  >5 publications with NRF1 and Skin
 Testis Antibodies  >5 publications with NRF1 and Testis
 Bone Antibodies  >4 publications with NRF1 and Bone
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