NP_036993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
methylated-DNA--protein-cysteine methyltransferase
NCBI Official Synonym Full Names
O-6-methylguanine-DNA methyltransferase
NCBI Protein Information
methylated-DNA--protein-cysteine methyltransferase
UniProt Protein Name
Methylated-DNA--protein-cysteine methyltransferase
UniProt Synonym Protein Names
6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
UniProt Synonym Gene Names
NCBI Summary for MGMT
enzyme involved in DNA repair of O(6)-alkylguanine which is the major mutagenic and carcinogenic lesion in DNA [RGD, Feb 2006]
UniProt Comments for MGMT
MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.
Protein type: Apoptosis; DNA repair, damage; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: membrane; nucleoplasm; nucleus
Molecular Function: calcium ion binding; DNA binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity
Biological Process: cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; DNA repair; methylation; negative regulation of apoptosis; positive regulation of DNA repair; regulation of caspase activity; response to drug; response to ethanol; response to folic acid; response to organic cyclic compound; response to toxin
Research Articles on MGMT
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Products associated with anti-MGMT antibody
Diseases associated with anti-MGMT antibody
Organs/Tissues associated with anti-MGMT antibody
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