NP_859529.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,494 Da
NCBI Official Full Name
free fatty acid receptor 4 isoform GPR120-L
NCBI Official Synonym Full Names
free fatty acid receptor 4
NCBI Official Synonym Symbols
GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1 [Similar Products]
NCBI Protein Information
free fatty acid receptor 4; omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4
UniProt Protein Name
Free fatty acid receptor 4
UniProt Synonym Protein Names
G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Omega-3 fatty acid receptor 1
UniProt Synonym Gene Names
UniProt Entry Name
FFAR4_HUMAN
NCBI Summary for O3FAR1
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for O3FAR1
GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Lipid-binding; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: endocytic vesicle; integral to plasma membrane; plasma membrane
Molecular Function: peptide binding; fatty acid binding; taste receptor activity
Biological Process: hormone secretion; G-protein coupled receptor protein signaling pathway; negative regulation of inflammatory response; negative regulation of cytokine secretion; detection of chemical stimulus involved in sensory perception of taste; cellular response to hormone stimulus; negative regulation of apoptosis
Disease: Body Mass Index Quantitative Trait Locus 10
Research Articles on O3FAR1
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Products associated with anti-O3FAR1 antibody
Pathways associated with anti-O3FAR1 antibody
Diseases associated with anti-O3FAR1 antibody
Organs/Tissues associated with anti-O3FAR1 antibody
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