NP_001027581.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,944 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 1 isoform 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 1, 40/46kDa
NCBI Protein Information
2'-5'-oligoadenylate synthase 1; (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1 p48 isoform; 2'-5' oligoadenylate synthetase 1 p52 isoform; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E18/E16; p46/p42 OAS
UniProt Protein Name
2'-5'-oligoadenylate synthase 1
UniProt Synonym Protein Names
E18/E16; p46/p42 OAS
UniProt Synonym Gene Names
UniProt Entry Name
OAS1_HUMAN
NCBI Summary for OAS1
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for OAS1
OAS1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.7.84; Transferase
Chromosomal Location of Human Ortholog: 12q24.2
Cellular Component: mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; cytosol; nucleus
Molecular Function: protein binding; zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity
Biological Process: negative regulation of viral genome replication; cytokine and chemokine mediated signaling pathway; response to virus; glucose metabolic process; purine nucleotide biosynthetic process; glucose homeostasis; defense response to virus; protein oligomerization
Disease: Diabetes Mellitus, Insulin-dependent
Research Articles on OAS1
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Pathways associated with anti-OAS1 antibody
Diseases associated with anti-OAS1 antibody
Organs/Tissues associated with anti-OAS1 antibody
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