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anti-OAS1 antibody :: Rabbit anti-Human OAS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240868
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OAS1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human OAS1

 Product Synonym Names    Anti-OAS1 Antibody IHC-plus; OAS1; 2;5-oligo A synthetase 1; 2-5A synthetase 1; 2-5A synthase 1; 2-5-oligoadenylate synthase 1; E18/E16; OIASI; OIAS; p46/p42 OAS; IFI-4; Human OAS1
 Product Gene Name   

anti-OAS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164350
 3D Structure    ModBase 3D Structure for P00973
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human OAS1.
 Immunogen Type    Synthetic peptide
 Immunogen    OAS1 antibody was raised against synthetic peptide from human OAS1.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-OAS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-OAS1 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-OAS1 antibody    ELISA (1:000 - 1:1000), IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-OAS1 antibody    Anti-OAS1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-OAS1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for OAS1. It may not necessarily be applicable to this product.
 NCBI GI #    74229013
 NCBI GeneID    4938
 NCBI Accession #    NP_058132.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016816.2 [Other Products]
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 UniProt Primary Accession #    P00973 [Other Products]
 UniProt Secondary Accession #    P04820; P29080; P29081; P78485; P78486; Q16700; Q16701; Q1PG42; Q3ZM01; Q53GC5; A8K4N8 [Other Products]
 UniProt Related Accession #    P00973 [Other Products]
 Molecular Weight    43,944 Da
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 NCBI Official Full Name    2'-5'-oligoadenylate synthase 1 isoform 1
 NCBI Official Synonym Full Names    2'-5'-oligoadenylate synthetase 1, 40/46kDa
 NCBI Official Symbol    OAS1 [Similar Products]
 NCBI Official Synonym Symbols   
OIAS; IFI-4; OIASI
[Similar Products]
 NCBI Protein Information    2'-5'-oligoadenylate synthase 1; E18/E16; p46/p42 OAS; 2-5A synthase 1; 2-5A synthetase 1; (2-5')oligo(A) synthase 1; 2',5'-oligo A synthetase 1; (2-5')oligo(A) synthetase 1; 2'-5'-oligoisoadenylate synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1 p48 isoform; 2'-5' oligoadenylate synthetase 1 p52 isoform
 UniProt Protein Name    2'-5'-oligoadenylate synthase 1
 UniProt Synonym Protein Names   
E18/E16; p46/p42 OAS
 Protein Family    2'-5'-oligoadenylate synthase
 UniProt Gene Name    OAS1 [Similar Products]
 UniProt Synonym Gene Names    OIAS; (2-5')oligo(A) synthase 1; 2-5A synthase 1 [Similar Products]
 UniProt Entry Name    OAS1_HUMAN
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 NCBI Summary for OAS1    This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for OAS1    OAS1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.7.7.84

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; cytosol; nucleus

Molecular Function: protein binding; zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: negative regulation of viral genome replication; response to virus; cytokine and chemokine mediated signaling pathway; glucose metabolic process; purine nucleotide biosynthetic process; glucose homeostasis; defense response to virus; protein oligomerization

Disease: Diabetes Mellitus, Insulin-dependent
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 Research Articles on OAS1    1. protein expression is inhibited by hepatitis C virus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-OAS1 antibodyDiseases associated with anti-OAS1 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Virus Diseases Antibodies  >59 publications with OAS1 and Virus Diseases
 Liver Diseases Antibodies  >26 publications with OAS1 and Liver Diseases
 Inflammation Antibodies  >16 publications with OAS1 and Inflammation
 Carcinoma Antibodies  >11 publications with OAS1 and Carcinoma
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with OAS1 and Diabetes Mellitus, Type 1
 Necrosis Antibodies  >6 publications with OAS1 and Necrosis
 Influenza, Human Antibodies  >5 publications with OAS1 and Influenza, Human
 Neoplasms, Experimental Antibodies  >4 publications with OAS1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >3 publications with OAS1 and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >3 publications with OAS1 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-OAS1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with OAS1 and Blood
 Liver Antibodies  >21 publications with OAS1 and Liver
 Lung Antibodies  >8 publications with OAS1 and Lung
 Muscle Antibodies  >7 publications with OAS1 and Muscle
 Brain Antibodies  >6 publications with OAS1 and Brain
 Prostate Antibodies  >5 publications with OAS1 and Prostate
 Kidney Antibodies  >5 publications with OAS1 and Kidney
 Uterus Antibodies  >4 publications with OAS1 and Uterus
 Mouth Antibodies  >4 publications with OAS1 and Mouth
 Bone Antibodies  >3 publications with OAS1 and Bone
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