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anti-OAS2 antibody :: Rabbit anti-Human, Mouse OAS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9402391
Testing Data
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OAS2, Polyclonal Antibody

★Popular Item★
 Also Known As   

OAS2 Antibody

 Product Synonym Names    MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS
 Product Gene Name   

anti-OAS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603350
 3D Structure    ModBase 3D Structure for P29728
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total OAS2 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    0.6 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Fusion protein corresponding to a region derived from internal residues of human 2'-5'-oligoadenylate synthetase 2, 69/71kDa
 Target Name    OAS2
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-OAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-OAS2 antibody

   This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
 Product Categories/Family for anti-OAS2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-OAS2 antibody   

Western Blot (WB)

 Application Notes for anti-OAS2 antibody    Western blotting: 1:200-1:1000
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 Testing Data of anti-OAS2 antibody    Gel: 10%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds
anti-OAS2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for OAS2. It may not necessarily be applicable to this product.
 NCBI GI #    74229021
 NCBI GeneID    4939
 NCBI Accession #    NP_001027903.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001032731.1 [Other Products]
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 UniProt Primary Accession #    P29728 [Other Products]
 UniProt Secondary Accession #    Q6PJ33; Q86XX8; A8K9T1 [Other Products]
 UniProt Related Accession #    P29728 [Other Products]
 Molecular Weight    19,517 Da
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 NCBI Official Full Name    2'-5'-oligoadenylate synthase 2 isoform 3
 NCBI Official Synonym Full Names    2'-5'-oligoadenylate synthetase 2, 69/71kDa
 NCBI Official Symbol    OAS2 [Similar Products]
 NCBI Protein Information    2'-5'-oligoadenylate synthase 2
 UniProt Protein Name    2'-5'-oligoadenylate synthase 2
 UniProt Synonym Protein Names   
p69 OAS / p71 OAS; p69OAS / p71OAS
 Protein Family    2'-5'-oligoadenylate synthase
 UniProt Gene Name    OAS2 [Similar Products]
 UniProt Synonym Gene Names    (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS [Similar Products]
 UniProt Entry Name    OAS2_HUMAN
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 NCBI Summary for OAS2    This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for OAS2    OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: membrane; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: response to virus; cytokine and chemokine mediated signaling pathway; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; RNA catabolic process; protein myristoylation; protein amino acid glycosylation; purine nucleotide biosynthetic process; defense response to virus
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 Research Articles on OAS2    1. Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OAS2 antibodyPathways associated with anti-OAS2 antibody
 Reference Product  PubMed Publications
 MX1 antibody  >12 publications with OAS2 and MX1
 ISG15 antibody  >5 publications with OAS2 and ISG15
 IRF7 antibody  >3 publications with OAS2 and IRF7
 MX2 antibody  >3 publications with OAS2 and MX2
 IFIT1 antibody  >3 publications with OAS2 and IFIT1
 IFI27 antibody  >2 publications with OAS2 and IFI27
 RNASEL antibody  >2 publications with OAS2 and RNASEL
 IFIT2 antibody  >1 publications with OAS2 and IFIT2
 IFIT3 antibody  >1 publications with OAS2 and IFIT3
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
Diseases associated with anti-OAS2 antibodyOrgans/Tissues associated with anti-OAS2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >10 publications with OAS2 and Liver Diseases
 Skin Diseases Antibodies  >4 publications with OAS2 and Skin Diseases
 Inflammation Antibodies  >3 publications with OAS2 and Inflammation
 Necrosis Antibodies  >3 publications with OAS2 and Necrosis
 Atherosclerosis Antibodies  >2 publications with OAS2 and Atherosclerosis
 Fibrosis Antibodies  >2 publications with OAS2 and Fibrosis
 Pneumonia Antibodies  >1 publications with OAS2 and Pneumonia
 Carcinoma, Hepatocellular Antibodies  >1 publications with OAS2 and Carcinoma, Hepatocellular
 Prostatic Diseases Antibodies  >1 publications with OAS2 and Prostatic Diseases
 Cardiovascular Diseases Antibodies  >1 publications with OAS2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with OAS2 and Blood
 Skin Antibodies  >7 publications with OAS2 and Skin
 Liver Antibodies  >6 publications with OAS2 and Liver
 Vascular Antibodies  >3 publications with OAS2 and Vascular
 Spleen Antibodies  >3 publications with OAS2 and Spleen
 Lung Antibodies  >2 publications with OAS2 and Lung
 Muscle Antibodies  >1 publications with OAS2 and Muscle
 Brain Antibodies  >1 publications with OAS2 and Brain
 Mouth Antibodies  >1 publications with OAS2 and Mouth
 Bone Marrow Antibodies  >1 publications with OAS2 and Bone Marrow
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