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anti-Oasl2 antibody :: Rabbit anti-Human OASL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS630945 anti-Oasl2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OASL (Oasl2), Polyclonal Antibody

 Also Known As   

OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)

 Product Synonym Names    Anti -OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)
 Product Gene Name   

anti-Oasl2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000071.6 (114896934..114912245). Location: 5 F; 5
 3D Structure    ModBase 3D Structure for Q9Z2F2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human OASL.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the C-terminal region of human OASL (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Oasl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Oasl2 antibody

   2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514aa human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
 Product Categories/Family for anti-Oasl2 antibody    Antibodies; Abs to Enzymes, Synthase
 Applications Tested/Suitable for anti-Oasl2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Oasl2 antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for Oasl2. It may not necessarily be applicable to this product.
 NCBI GI #    21707766
 NCBI GeneID    23962
 NCBI Accession #    AAH34361.1 [Other Products]
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 UniProt Primary Accession #    Q9Z2F2 [Other Products]
 UniProt Secondary Accession #    Q9D6S2 [Other Products]
 UniProt Related Accession #    Q9Z2F2 [Other Products]
 Molecular Weight    58,767 Da [Similar Products]
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 NCBI Official Full Name    Oasl2 protein
 NCBI Official Synonym Full Names    2'-5' oligoadenylate synthetase-like 2
 NCBI Official Symbol    Oasl2 [Similar Products]
 NCBI Official Synonym Symbols   
Oasl; M1204; Mmu-OASL
[Similar Products]
 NCBI Protein Information    2'-5'-oligoadenylate synthase-like protein 2; p54OASL; p54 OASL; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2
 UniProt Protein Name    2'-5'-oligoadenylate synthase-like protein 2
 UniProt Synonym Protein Names   
54 kDa 2'-5'-oligoadenylate synthase-like protein; p54 OASL; M1204
 Protein Family    2'-5'-oligoadenylate synthase-like protein
 UniProt Gene Name    Oasl2 [Similar Products]
 UniProt Synonym Gene Names    p54 OASL [Similar Products]
 UniProt Entry Name    OASL2_MOUSE
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 UniProt Comments for Oasl2    Oasl2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family.

Protein type: EC 2.7.7.84

Molecular Function: transferase activity; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; ATP binding; 2'-5'-oligoadenylate synthetase activity; nucleotidyltransferase activity

Biological Process: immune system process; response to virus; innate immune response; immune response; purine nucleotide biosynthetic process; defense response to virus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Oasl2 antibodyPathways associated with anti-Oasl2 antibody
 Reference Product  PubMed Publications
 Ifit1 antibody  >3 publications with Oasl2 and Ifit1
 Zbp1 antibody  >1 publications with Oasl2 and Zbp1
 Isg15 antibody  >1 publications with Oasl2 and Isg15
 Usp18 antibody  >1 publications with Oasl2 and Usp18
 Irf7 antibody  >1 publications with Oasl2 and Irf7
 Rtp4 antibody  >1 publications with Oasl2 and Rtp4
 Ifi44 antibody  >1 publications with Oasl2 and Ifi44
 Products by Pathway  Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with anti-Oasl2 antibodyOrgans/Tissues associated with anti-Oasl2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with Oasl2 and Inflammation
 Neoplasms Antibodies  >1 publications with Oasl2 and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >1 publications with Oasl2 and Uncharacterized Tissue
 Skin Antibodies  >1 publications with Oasl2 and Skin
 Lymph Node Antibodies  >1 publications with Oasl2 and Lymph Node
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