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anti-SLCO1A2 antibody :: Rabbit anti-Human OATP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS614232 anti-SLCO1A2 antibody
Unit / Price
0.1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OATP (SLCO1A2), Polyclonal Antibody

 Also Known As   

OATP (Organic anion transporting polypeptide)

 Product Synonym Names    Anti -OATP (Organic anion transporting polypeptide)
 Product Gene Name   

anti-SLCO1A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (21417534..21548371, complement). Location: 12p12
 OMIM    602883
 3D Structure    ModBase 3D Structure for P46721
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human OATP. No significant sequence homology is detected with other oatp1-3 or human LST-1.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.
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 Immunogen    A 15aa peptide internal sequence (middle regions) of human OATP (KLH). Epitope: ~C-terminus extracellular domain (gene accession # P46721). Species sequence homology: chimp 100%.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SLCO1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SLCO1A2 antibody

   Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus).
 Product Categories/Family for anti-SLCO1A2 antibody    Antibodies; Abs to Ion Channel
 Applications Tested/Suitable for anti-SLCO1A2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-SLCO1A2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml using ECL.
ELISA: 0.5-1ug/ml. Control peptide can be used to coat plates at 1ug/ml.
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NCBI/Uniprot data below describe general gene information for SLCO1A2. It may not necessarily be applicable to this product.
 NCBI GI #    885978
 NCBI GeneID    6579
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 UniProt Primary Accession #    P46721 [Other Products]
 UniProt Secondary Accession #    Q9UGP7; Q9UL38 [Other Products]
 UniProt Related Accession #    P46721; Q8IV69 [Other Products]
 Molecular Weight    74,145 Da [Similar Products]
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 NCBI Official Full Name    organic anion transporting polypeptide
 NCBI Official Synonym Full Names    solute carrier organic anion transporter family, member 1A2
 NCBI Official Symbol    SLCO1A2 [Similar Products]
 NCBI Official Synonym Symbols   
OATP; OATP-A; OATP1A2; SLC21A3
[Similar Products]
 NCBI Protein Information    solute carrier organic anion transporter family member 1A2; OATP-1; OTTHUMP00000209604; OTTHUMP00000209605; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3
 UniProt Protein Name    Solute carrier organic anion transporter family member 1A2
 UniProt Synonym Protein Names   
OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
 Protein Family    Solute carrier organic anion transporter family
 UniProt Gene Name    SLCO1A2 [Similar Products]
 UniProt Synonym Gene Names    OATP; OATP1; OATP1A2; SLC21A3 [Similar Products]
 UniProt Entry Name    SO1A2_HUMAN
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 NCBI Summary for SLCO1A2    This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for SLCO1A2    SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: plasma membrane; integral to membrane

Molecular Function: organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
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 Research Articles on SLCO1A2    1. Although imatinib is indicated as a substrate for OATP1A2, this transporter by itself is unlikely to contribute substantially to the absorption profiles of imatinib in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLCO1A2 antibodyDiseases associated with anti-SLCO1A2 antibody
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Recycling Of Bile Acids And Salts Pathway antibodies  Recycling Of Bile Acids And Salts Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Organic Anions Pathway antibodies  Transport Of Organic Anions Pathway Diagram
 Transport Of Vitamins, Nucleosides, And Related Molecules Pathway antibodies  Transport Of Vitamins, Nucleosides, And Related Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with SLCO1A2 and Liver Diseases
 Drug Toxicity Antibodies  >3 publications with SLCO1A2 and Drug Toxicity
 Kidney Diseases Antibodies  >2 publications with SLCO1A2 and Kidney Diseases
 Breast Neoplasms Antibodies  >2 publications with SLCO1A2 and Breast Neoplasms
 Epilepsy Antibodies  >1 publications with SLCO1A2 and Epilepsy
 Fibrosis Antibodies  >1 publications with SLCO1A2 and Fibrosis
 Kidney Neoplasms Antibodies  >1 publications with SLCO1A2 and Kidney Neoplasms
 Autoimmune Diseases Antibodies  >1 publications with SLCO1A2 and Autoimmune Diseases
 Neoplasms, Hormone-Dependent Antibodies  >1 publications with SLCO1A2 and Neoplasms, Hormone-Dependent
 Pregnancy Complications Antibodies  >1 publications with SLCO1A2 and Pregnancy Complications
Organs/Tissues associated with anti-SLCO1A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with SLCO1A2 and Liver
 Kidney Antibodies  >11 publications with SLCO1A2 and Kidney
 Brain Antibodies  >11 publications with SLCO1A2 and Brain
 Mouth Antibodies  >1 publications with SLCO1A2 and Mouth
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