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anti-OAZ1 antibody :: Rabbit OAZ1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8222066
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OAZ1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-OAZ1 Antibody

 Product Synonym Names    OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
 Product Gene Name   

anti-OAZ1 antibody

[Similar Products]
 Antibody/Peptide Pairs    OAZ1 peptide (MBS8227400) is used for blocking the activity of OAZ1 antibody (MBS8222066)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601579
 3D Structure    ModBase 3D Structure for P54368
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of OAZ1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human OAZ1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-OAZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-OAZ1 antibody

   Rabbit polyclonal antibody to OAZ1
 Applications Tested/Suitable for anti-OAZ1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-OAZ1 antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200)
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 Western Blot (WB) of anti-OAZ1 antibody    Western blot analysis of OAZ1 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.
anti-OAZ1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-OAZ1 antibody    Immunohistochemical analysis of OAZ1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-OAZ1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for OAZ1. It may not necessarily be applicable to this product.
 NCBI GI #    9845505
 NCBI GeneID    4946
 NCBI Accession #    NP_004143.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004152.3 [Other Products]
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 UniProt Primary Accession #    P54368 [Other Products]
 UniProt Secondary Accession #    O43382; Q14989; Q92595; Q9UPL9 [Other Products]
 UniProt Related Accession #    P54368 [Other Products]
 Molecular Weight    25,406 Da
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 NCBI Official Full Name    ornithine decarboxylase antizyme 1 isoform 1
 NCBI Official Synonym Full Names    ornithine decarboxylase antizyme 1
 NCBI Official Symbol    OAZ1 [Similar Products]
 NCBI Official Synonym Symbols   
AZI; OAZ
[Similar Products]
 NCBI Protein Information    ornithine decarboxylase antizyme 1
 UniProt Protein Name    Ornithine decarboxylase antizyme 1
 Protein Family    Ornithine decarboxylase antizyme
 UniProt Gene Name    OAZ1 [Similar Products]
 UniProt Synonym Gene Names    OAZ; ODC-Az [Similar Products]
 UniProt Entry Name    OAZ1_HUMAN
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 NCBI Summary for OAZ1    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for OAZ1    OAZ1: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol

Molecular Function: protein binding; ornithine decarboxylase inhibitor activity

Biological Process: transport; polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; regulation of amino acid metabolic process
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 Research Articles on OAZ1    1. Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OAZ1 antibodyPathways associated with anti-OAZ1 antibody
 Reference Product  PubMed Publications
 OAZ2 antibody  >8 publications with OAZ1 and OAZ2
 OAZ3 antibody  >3 publications with OAZ1 and OAZ3
 ODC1 antibody  >1 publications with OAZ1 and ODC1
 Products by Pathway  Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 Regulation Of Ornithine Decarboxylase (ODC) Pathway antibodies  Regulation Of Ornithine Decarboxylase (ODC) Pathway Diagram
Diseases associated with anti-OAZ1 antibodyOrgans/Tissues associated with anti-OAZ1 antibody
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >4 publications with OAZ1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >3 publications with OAZ1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with OAZ1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with OAZ1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with OAZ1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with OAZ1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with OAZ1 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with OAZ1 and Kidney Diseases
 Heart Diseases Antibodies  >1 publications with OAZ1 and Heart Diseases
 Disease Models, Animal Antibodies  >1 publications with OAZ1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with OAZ1 and Testis
 Mouth Antibodies  >4 publications with OAZ1 and Mouth
 Ovary Antibodies  >3 publications with OAZ1 and Ovary
 Brain Antibodies  >3 publications with OAZ1 and Brain
 Blood Antibodies  >2 publications with OAZ1 and Blood
 Lung Antibodies  >2 publications with OAZ1 and Lung
 Kidney Antibodies  >1 publications with OAZ1 and Kidney
 Liver Antibodies  >1 publications with OAZ1 and Liver
 Intestine Antibodies  >1 publications with OAZ1 and Intestine
 Uterus Antibodies  >1 publications with OAZ1 and Uterus
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