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anti-OAZ3 antibody :: Rabbit OAZ3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820798
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OAZ3, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-OAZ3 Antibody

 Product Synonym Names    Ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3
 Product Gene Name   

anti-OAZ3 antibody

[Similar Products]
 Antibody/Peptide Pairs    OAZ3 peptide (MBS824211) is used for blocking the activity of OAZ3 antibody (MBS820798)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605138
 3D Structure    ModBase 3D Structure for Q9UMX2
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of OAZ3 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human OAZ3. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-OAZ3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-OAZ3 antibody

   Rabbit polyclonal antibody to OAZ3
 Applications Tested/Suitable for anti-OAZ3 antibody   

Western Blot (WB)

 Application Notes for anti-OAZ3 antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-OAZ3 antibody    Western blot analysis of OAZ3 expression in HEK293T (A), Jurkat (B), mouse testis (C), rat testis (D) whole cell lysates.
anti-OAZ3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for OAZ3. It may not necessarily be applicable to this product.
 NCBI GI #    201023343
 NCBI GeneID    51686
 NCBI Accession #    NP_001128411.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001134939.1 [Other Products]
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 UniProt Primary Accession #    Q9UMX2 [Other Products]
 UniProt Secondary Accession #    Q6GMR0; E7EUE7 [Other Products]
 UniProt Related Accession #    Q9UMX2 [Other Products]
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 NCBI Official Full Name    ornithine decarboxylase antizyme 3 isoform 2
 NCBI Official Synonym Full Names    ornithine decarboxylase antizyme 3
 NCBI Official Symbol    OAZ3 [Similar Products]
 NCBI Official Synonym Symbols   
AZ3; OAZ-t; TISP15
[Similar Products]
 NCBI Protein Information    ornithine decarboxylase antizyme 3; ODC-Az 3
 UniProt Protein Name    Ornithine decarboxylase antizyme 3
 Protein Family    Ornithine decarboxylase antizyme
 UniProt Gene Name    OAZ3 [Similar Products]
 UniProt Synonym Gene Names    AZ3; ODC-Az 3 [Similar Products]
 UniProt Entry Name    OAZ3_HUMAN
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 NCBI Summary for OAZ3    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014]
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 UniProt Comments for OAZ3    OAZ3: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; putrescine transmembrane transporter activity; ornithine decarboxylase inhibitor activity

Biological Process: polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; spermatogenesis; regulation of phosphoprotein phosphatase activity; regulation of amino acid metabolic process; putrescine transport
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 Research Articles on OAZ3    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OAZ3 antibodyPathways associated with anti-OAZ3 antibody
 Reference Product  PubMed Publications
 OAZ2 antibody  >3 publications with OAZ3 and OAZ2
 OAZ1 antibody  >3 publications with OAZ3 and OAZ1
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Regulation Of Ornithine Decarboxylase (ODC) Pathway antibodies  Regulation Of Ornithine Decarboxylase (ODC) Pathway Diagram
Diseases associated with anti-OAZ3 antibodyOrgans/Tissues associated with anti-OAZ3 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >1 publications with OAZ3 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >7 publications with OAZ3 and Testis
 Lung Antibodies  >1 publications with OAZ3 and Lung
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