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anti-OCT2 antibody :: Rabbit OCT2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS300913
Immunohistochemistry (IHC)
Unit / Price
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 Product Name   

OCT2, Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human OCT-2 Polyclonal Antibody

 Product Gene Name   

anti-OCT2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164176
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Dog, Mouse, Pig, Rabbit
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from C-terminus of human OCT-2.
 Control Tissue    Tonsil
 Cellular Localization    Nucleus
 Entrez Gene Code    5452
 Pathway    Signal Transduction
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-OCT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-OCT2 antibody

   Oct-2 is a transcription factor belonging to the POU homeo-domain family that binds to the Ig gene octomer sites regulating B cell specific genes. Oct-2 protein expression is not restricted to B cells, although expression levels are much higher in these cells. Oct-2 expression is reported to be significantly greater in germinal center derived lymphomas, although other B cell lymphomas also display high levels of expression.
 Applications Tested/Suitable for anti-OCT2 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-OCT2 antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:50
IHC Positive Control: Tonsil
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 Immunohistochemistry (IHC) of anti-OCT2 antibody    Human tonsil stained with anti-Oct-2 antibody
anti-OCT2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for OCT2. It may not necessarily be applicable to this product.
 NCBI GI #    333360875
 NCBI GeneID    5452
 NCBI Accession #    NP_001193954.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207025.2 [Other Products]
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 UniProt Secondary Accession #    Q16648; Q7M4M8; Q9BRS4 [Other Products]
 UniProt Related Accession #    P09086 [Other Products]
 Molecular Weight    ~80 kDa
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 NCBI Official Full Name    POU domain, class 2, transcription factor 2 isoform 1
 NCBI Official Synonym Full Names    POU class 2 homeobox 2
 NCBI Official Symbol    POU2F2 [Similar Products]
 NCBI Official Synonym Symbols   
OCT2; OTF2; Oct-2
[Similar Products]
 NCBI Protein Information    POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; octamer-binding protein 2; octamer-binding transcription factor 2
 UniProt Protein Name    POU domain, class 2, transcription factor 2
 UniProt Synonym Protein Names   
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2; OTF-2
 UniProt Gene Name    POU2F2 [Similar Products]
 UniProt Synonym Gene Names    OCT2; OTF2; Oct-2; OTF-2 [Similar Products]
 UniProt Entry Name    PO2F2_HUMAN
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 NCBI Summary for OCT2    The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for OCT2    Oct2: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor activity

Biological Process: immunoglobulin secretion during immune response; transcription from RNA polymerase II promoter; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response
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 Research Articles on OCT2    1. a differential control exerted by both Oct-1 and Oct-2 in the transcriptional regulation of the HMGA1 gene
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OCT2 antibodyPathways associated with anti-OCT2 antibody
 Reference Product  PubMed Publications
 POU2AF1 antibody  >38 publications with OCT2 and POU2AF1
 TBP antibody  >4 publications with OCT2 and TBP
 HMGA1 antibody  >3 publications with OCT2 and HMGA1
 RELA antibody  >1 publications with OCT2 and RELA
 Products by Pathway  Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-OCT2 antibodyOrgans/Tissues associated with anti-OCT2 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >33 publications with OCT2 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >4 publications with OCT2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >3 publications with OCT2 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with OCT2 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with OCT2 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with OCT2 and Necrosis
 Liver Neoplasms Antibodies  >1 publications with OCT2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with OCT2 and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with OCT2 and Fibrosis
 Hyperplasia Antibodies  >1 publications with OCT2 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with OCT2 and Blood
 Brain Antibodies  >23 publications with OCT2 and Brain
 Lymph Node Antibodies  >8 publications with OCT2 and Lymph Node
 Lymph Antibodies  >7 publications with OCT2 and Lymph
 Bone Antibodies  >6 publications with OCT2 and Bone
 Embryonic Tissue Antibodies  >3 publications with OCT2 and Embryonic Tissue
 Liver Antibodies  >3 publications with OCT2 and Liver
 Kidney Antibodies  >2 publications with OCT2 and Kidney
 Tonsil Antibodies  >2 publications with OCT2 and Tonsil
 Testis Antibodies  >2 publications with OCT2 and Testis
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