NP_001177747.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
origin recognition complex subunit 1 isoform 1
NCBI Official Synonym Full Names
origin recognition complex subunit 1
NCBI Protein Information
origin recognition complex subunit 1
UniProt Protein Name
Origin recognition complex subunit 1
UniProt Synonym Protein Names
Replication control protein 1
UniProt Synonym Gene Names
NCBI Summary for ORC1L
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for ORC1L
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Research Articles on ORC1L
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Products associated with anti-ORC1L antibody
Pathways associated with anti-ORC1L antibody
Diseases associated with anti-ORC1L antibody
Organs/Tissues associated with anti-ORC1L antibody
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