NP_859531.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
origin recognition complex subunit 5 isoform 2
NCBI Official Synonym Full Names
origin recognition complex, subunit 5
NCBI Protein Information
origin recognition complex subunit 5; protein phosphatase 1, regulatory subunit 117
UniProt Protein Name
Origin recognition complex subunit 5
UniProt Entry Name
ORC5_HUMAN
NCBI Summary for ORC5L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
UniProt Comments for ORC5L
ORC5L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC5 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; cytoplasm; nucleus; nuclear origin of replication recognition complex; origin recognition complex
Molecular Function: protein binding; nucleotide binding; DNA replication origin binding; ATP binding
Biological Process: DNA replication initiation; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
Product References and Citations for anti-ORC5L antibody
(1) Siddiqui,K. and Stillman,B. ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282 (44), 32370-32383 (2007).
Research Articles on ORC5L
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Pathways associated with anti-ORC5L antibody
Organs/Tissues associated with anti-ORC5L antibody
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