NP_055650.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,971 Da
NCBI Official Full Name
oxysterol-binding protein-related protein 2 isoform 1
NCBI Official Synonym Full Names
oxysterol binding protein like 2
NCBI Protein Information
oxysterol-binding protein-related protein 2
UniProt Protein Name
Oxysterol-binding protein-related protein 2
UniProt Synonym Gene Names
UniProt Entry Name
OSBL2_HUMAN
NCBI Summary for OSBPL2
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
UniProt Comments for OSBPL2
OSBPL2: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Belongs to the OSBP family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 20q13.33
Molecular Function: cholesterol binding; protein binding
Biological Process: lipid transport
Disease: Deafness, Autosomal Dominant 67
Research Articles on OSBPL2
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Products associated with anti-OSBPL2 antibody
Diseases associated with anti-OSBPL2 antibody
Organs/Tissues associated with anti-OSBPL2 antibody
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