NP_005100.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,022 Da
NCBI Official Full Name
serine/threonine-protein kinase OSR1
NCBI Official Synonym Full Names
oxidative stress responsive 1
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
UniProt Entry Name
OXSR1_HUMAN
NCBI Summary for OSR1
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
UniProt Comments for OSR1
OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.11.1; STE group; STE20 family; FRAY subfamily
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
Research Articles on OSR1
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Products associated with anti-OSR1 antibody
Diseases associated with anti-OSR1 antibody
Organs/Tissues associated with anti-OSR1 antibody
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