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anti-BGLAP antibody :: Rabbit OSTEOCALCIN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222286 anti-BGLAP antibody
Unit / Price
0.25 mL  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OSTEOCALCIN (BGLAP), Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN OSTEOCALCIN

 Product Gene Name   

anti-BGLAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112260
 3D Structure    ModBase 3D Structure for P02818
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine, Dog, Monkey
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 Specificity    This item is specific for intact osteocalcin and recognizes an epitope towards the C-terminal of the molecule. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.
 Form/Format    Serum
Serum - liquid
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
 Immunogen    Human osteocalcin
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-BGLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BGLAP antibody

   MBS222286 is specific for intact osteocalcin and recognizes an epitope towards the C-terminal of the molecule.Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.
 Applications Tested/Suitable for anti-BGLAP antibody   

Immunohistology Frozen

 Application Notes for anti-BGLAP antibody    Immunohistology: This item is suitable for staining cultured human osteoblasts after fixation with 2% formaldehyde and permeabilization.
Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/50
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NCBI/Uniprot data below describe general gene information for BGLAP. It may not necessarily be applicable to this product.
 NCBI GI #    40316933
 NCBI GeneID    632
 NCBI Accession #    NP_954642.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199173.4 [Other Products]
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 UniProt Primary Accession #    P02818 [Other Products]
 UniProt Secondary Accession #    Q5TCK6 [Other Products]
 UniProt Related Accession #    P02818 [Other Products]
 Molecular Weight    10,963 Da [Similar Products]
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 NCBI Official Full Name    osteocalcin preproprotein
 NCBI Official Synonym Full Names    bone gamma-carboxyglutamate (gla) protein
 NCBI Official Symbol    BGLAP [Similar Products]
 NCBI Official Synonym Symbols   
OC; BGP; OCN
[Similar Products]
 NCBI Protein Information    osteocalcin; bone Gla protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein
 UniProt Protein Name    Osteocalcin
 UniProt Synonym Protein Names   
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
 Protein Family    Osteocalcin
 UniProt Gene Name    BGLAP [Similar Products]
 UniProt Synonym Gene Names    BGP [Similar Products]
 UniProt Entry Name    OSTCN_HUMAN
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 NCBI Summary for BGLAP    This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
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 UniProt Comments for BGLAP    osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon

Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity

Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; response to vitamin D; regulation of osteoclast differentiation; response to ethanol; response to vitamin K; response to estrogen stimulus; response to mechanical stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; skeletal development; regulation of bone mineralization
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 Research Articles on BGLAP    1. No correlation between total osteocalcin and fasting plasma glucose, fasting insulin and insulin resistance parameters was found in nondiabetic postmenopausal women. Serum levels of adiponectin were associated with metabolic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BGLAP antibodyPathways associated with anti-BGLAP antibody
 Reference Product  PubMed Publications
 RUNX2 antibody  >42 publications with BGLAP and RUNX2
 BMP2 antibody  >13 publications with BGLAP and BMP2
 VDR antibody  >4 publications with BGLAP and VDR
 TGFB1 antibody  >3 publications with BGLAP and TGFB1
 PTH antibody  >2 publications with BGLAP and PTH
 ATF4 antibody  >2 publications with BGLAP and ATF4
 LEP antibody  >1 publications with BGLAP and LEP
 PTHLH antibody  >1 publications with BGLAP and PTHLH
 Products by Pathway  Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with anti-BGLAP antibodyOrgans/Tissues associated with anti-BGLAP antibody
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >10 publications with BGLAP and Bone Diseases
 Osteoporosis Antibodies  >9 publications with BGLAP and Osteoporosis
 Inflammation Antibodies  >5 publications with BGLAP and Inflammation
 Nervous System Diseases Antibodies  >4 publications with BGLAP and Nervous System Diseases
 Calcinosis Antibodies  >3 publications with BGLAP and Calcinosis
 Kidney Diseases Antibodies  >2 publications with BGLAP and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2 publications with BGLAP and Cardiovascular Diseases
 Pain Antibodies  >2 publications with BGLAP and Pain
 Renal Insufficiency Antibodies  >1 publications with BGLAP and Renal Insufficiency
 Hypertension Antibodies  >1 publications with BGLAP and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >86 publications with BGLAP and Bone
 Brain Antibodies  >3 publications with BGLAP and Brain
 Parathyroid Antibodies  >2 publications with BGLAP and Parathyroid
 Prostate Antibodies  >2 publications with BGLAP and Prostate
 Lung Antibodies  >1 publications with BGLAP and Lung
 Heart Antibodies  >1 publications with BGLAP and Heart
 Intestine Antibodies  >1 publications with BGLAP and Intestine
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