NP_001516.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,536 Da
NCBI Official Full Name
orexin receptor 1
NCBI Official Synonym Full Names
hypocretin receptor 1
NCBI Official Synonym Symbols
NCBI Protein Information
orexin receptor type 1
UniProt Protein Name
Orexin receptor type 1
UniProt Synonym Protein Names
Hypocretin receptor type 1
UniProt Synonym Gene Names
UniProt Entry Name
OX1R_HUMAN
NCBI Summary for HCRTR1
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
UniProt Comments for HCRTR1
HCRTR1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; neuropeptide receptor activity; orexin receptor activity; peptide binding; peptide hormone binding
Biological Process: cellular response to hormone stimulus; feeding behavior; neuropeptide signaling pathway; regulation of circadian sleep/wake cycle, sleep; synaptic transmission
Research Articles on HCRTR1
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Pathways associated with anti-HCRTR1 antibody
Diseases associated with anti-HCRTR1 antibody
Organs/Tissues associated with anti-HCRTR1 antibody
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