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anti-OC antibody :: Rabbit anti-Rat Osteocalcin (OC) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2002197 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Osteocalcin (OC), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Osteocalcin (OC)

 Product Gene Name   

anti-OC antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
Biotin Conjugated Antibody: Osteocalcin (OC) (MBS2004068)
 Matching Pairs    Antibody: Osteocalcin (OC) (MBS2002197)
Antigen: Osteocalcin (OC) (MBS2011870)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
FITC Conjugated Antibody: Osteocalcin (OC) (MBS2013809)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
APC-CY7 Conjugated Antibody: Osteocalcin (OC) (MBS2042749)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
PE Conjugated Antibody: Osteocalcin (OC) (MBS2042750)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
APC-CY7 Conjugated Antibody: Osteocalcin (OC) (MBS2042751)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
Cy3 Conjugated Antibody: Osteocalcin (OC) (MBS2042752)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
HRP Conjugated Antibody: Osteocalcin (OC) (MBS2042753)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Osteocalcin (OC) (MBS2002197)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - ALTAFCLSDL AGAKPSDSES DKAFMSKQEG SKVVNRLRRY LNNGLGAPAP YPDPLEPHRE VCELNPNCDE LADHIGFQDA
 3D Structure    ModBase 3D Structure for P04640
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    The antibody is a rabbit polyclonal antibody raised against OC. It has been selected for its ability to recognize OC in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant OC (Ala11~Thr98) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2042751
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-OC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-OC antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-OC antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-OC antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-OC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-OC antibody    (DAB staining on IHC-P; Samples: Rat Testis Tissue)
anti-OC antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-OC antibody    (Used in DAB staining on formalin fixed paraffin- embedded kidney tissue)
anti-OC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for OC. It may not necessarily be applicable to this product.
 NCBI GI #    11761543
 NCBI GeneID    25295
 NCBI Accession #    NP_038200.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013414.1 [Other Products]
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 UniProt Primary Accession #    P04640 [Other Products]
 UniProt Related Accession #    P04640 [Other Products]
 Molecular Weight    10,927 Da
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 NCBI Official Full Name    osteocalcin preproprotein
 NCBI Official Synonym Full Names    bone gamma-carboxyglutamate protein
 NCBI Official Symbol    Bglap [Similar Products]
 NCBI Official Synonym Symbols   
Bgp; Bgpr; Bgpra; Bglap2
[Similar Products]
 NCBI Protein Information    osteocalcin
 UniProt Protein Name    Osteocalcin
 UniProt Synonym Protein Names   
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
 UniProt Gene Name    Bglap [Similar Products]
 UniProt Synonym Gene Names    Bglap2; BGP [Similar Products]
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 NCBI Summary for OC    highly conserved protein associated with mineralized bone matrix; protein is secreted by calcified tissues and is regulated by vitamin D3 [RGD, Feb 2006]
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 UniProt Comments for OC    osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: cell projection; cytoplasm; dendrite; extracellular region; extracellular space; Golgi apparatus; perikaryon; rough endoplasmic reticulum; vesicle

Molecular Function: calcium ion binding; structural constituent of bone

Biological Process: aging; biomineral formation; cell aging; odontogenesis; ossification; osteoblast development; osteoblast differentiation; regulation of bone mineralization; response to activity; response to drug; response to estrogen; response to ethanol; response to glucocorticoid stimulus; response to gravity; response to hydroxyisoflavone; response to inorganic substance; response to mechanical stimulus; response to nutrient levels; response to organic cyclic compound; response to testosterone stimulus; response to vitamin D; response to vitamin K; response to zinc ion
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 Research Articles on OC    1. This rat model of complete loss of osteocalcin provides a platform for further understanding the role of osteocalcin in disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-OC antibodyDiseases associated with anti-OC antibody
 Products by Pathway  Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Osteoblast Pathway antibodies  Osteoblast Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway antibodies  Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway Diagram
 Transport Of Gamma-carboxylated Protein Precursors From The Endoplasmic Reticulum To The Golgi Apparatus Pathway antibodies  Transport Of Gamma-carboxylated Protein Precursors From The Endoplasmic Reticulum To The Golgi Apparatus Pathway Diagram
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >17 publications with OC and Bone Diseases
 Osteoporosis Antibodies  >12 publications with OC and Osteoporosis
 Inflammation Antibodies  >6 publications with OC and Inflammation
 Nervous System Diseases Antibodies  >4 publications with OC and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with OC and Cardiovascular Diseases
 Kidney Diseases Antibodies  >3 publications with OC and Kidney Diseases
 Insulin Resistance Antibodies  >3 publications with OC and Insulin Resistance
 Calcinosis Antibodies  >3 publications with OC and Calcinosis
 Necrosis Antibodies  >2 publications with OC and Necrosis
 Hypertrophy Antibodies  >2 publications with OC and Hypertrophy
Organs/Tissues associated with anti-OC antibody
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with OC and Mixed
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