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anti-Cdkn2a antibody :: Goat P19ARF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422702
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P19ARF (Cdkn2a), Polyclonal Antibody

 Also Known As   

Goat anti-P19ARF (mouse) Antibody

 Product Synonym Names    Cdkn2a; cyclin-dependent kinase inhibitor 2A; RP23-166I8.5; ARF-INK4a; Arf; INK4a-ARF; Ink4a/Arf; MTS1; Pctr1; p16; p16(INK4a); p16INK4a; p19ARF; CDK4I; OTTMUSP00000008143; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (p16,; Arf antibody; ARF-INK4a antibody; CDK4I antibody; cyclin-dependent kinase 4 inhibitor A antibody; cyclin-dependent kinase inhibitor 2A antibody; cyclin-dependent kinase inhibitor 2A (p16; inhibits CDK4) antibody; cyclin-dependent kinase inhibitor 2A; isoforms 1/2 antibody; cyclin-dependent kinase inhibitor protein antibody; Ink4a/Arf antibody; INK4a-ARF antibody; mitochondrial smARF antibody; MTS1 antibody; OTTMUSP00000008143 antibody; p16 antibody; p16(INK4a) antibody; p16-INK4 antibody; p16INK4a antibody; p16-INK4a antibody; p19ARF antibody; Pctr1 antibody; RP23-166I8.5 antibody; Cdkn2a antibody; P19ARF (mouse)
 Product Gene Name   

anti-Cdkn2a antibody

[Similar Products]
 Product Synonym Gene Name    P19ARF [Similar Products]
 Antibody/Peptide Pairs    P19ARF peptide (MBS427702) is used for blocking the activity of P19ARF antibody (MBS422702)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RRGPHRNPGP GDDD
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Mouse
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RRGPHRNPGPGDDD, from the internal region of the protein sequence according to NP_034007.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize isoform p19ARF (NP_034007.1) only.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8613
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-Cdkn2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Cdkn2a antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-Cdkn2a antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 18kDa band observed in Mouse Kidney and Liver lysates (calculated MW of 19.2kDa according to NP_034007.1). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-Cdkn2a antibody    (0.3ug/ml) staining of Mouse Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-Cdkn2a antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Cdkn2a. It may not necessarily be applicable to this product.
 NCBI GI #    6753390
 NCBI GeneID    12578
 NCBI Accession #    NP_034007.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009877.2 [Other Products]
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 UniProt Secondary Accession #    Q4U255; Q9QXC7; Q9R051 [Other Products]
 UniProt Related Accession #    Q64364; P51480 [Other Products]
 Molecular Weight    17,941 Da
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 NCBI Official Full Name    cyclin-dependent kinase inhibitor 2A isoform 1
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 2A
 NCBI Official Symbol    Cdkn2a [Similar Products]
 NCBI Official Synonym Symbols   
Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 2A
 UniProt Protein Name    Tumor suppressor ARF
 UniProt Synonym Protein Names   
Alternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p19ARF
 Protein Family    Tumor suppressor
 UniProt Gene Name    Cdkn2a [Similar Products]
 UniProt Synonym Gene Names    ARF [Similar Products]
 UniProt Entry Name    ARF_MOUSE
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 UniProt Comments for Cdkn2a    p16-INK4A iso3: a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. The p16INK4A and p14ARF proteins are encoded by CDKN2A, a known tumour suppressor gene in multiple cancers. CDKN2A is inactivated in 72% of cases of lung squamous cell carcinoma: 21% by epigenetic silencing by methylation, 18% inactivating mutation, 4% by exon 1b skipping, and 29% by homozygous deletion. Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Li-Fraumeni syndrome, and the melanoma-astrocytoma syndrome. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. Four alternatively spliced p16 isoforms have been reported. Two alternatively spliced isoforms of ARF have been reported.

Protein type: Tumor suppressor; Cell cycle regulation; Nucleolus

Cellular Component: cytoplasm; granular component; mitochondrion; nuclear body; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: cyclin-dependent protein kinase inhibitor activity; DNA binding; NF-kappaB binding; p53 binding; protein binding; protein kinase binding; protein N-terminus binding; SUMO ligase activity; transcription factor activity; transcription factor binding; ubiquitin-protein ligase inhibitor activity

Biological Process: aging; apoptosis; apoptotic mitochondrial changes; caspase activation; cell aging; cell cycle; cell cycle arrest; epidermis development; G1/S transition of mitotic cell cycle; glucose homeostasis; inhibition of NF-kappaB transcription factor; mitochondrial depolarization; mitochondrion degradation; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein kinase activity; negative regulation of immature T cell proliferation in the thymus; negative regulation of mammary gland epithelial cell proliferation; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; negative regulation of ubiquitin-protein ligase activity; positive regulation of apoptosis; positive regulation of apoptosis involved in mammary gland involution; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein sumoylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein destabilization; protein polyubiquitination; protein stabilization; regulation of cyclin-dependent protein kinase activity; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of nucleocytoplasmic transport; regulation of protein export from nucleus; regulation of protein stability; regulation of transcription, DNA-dependent; response to drug; response to organic cyclic substance; response to organic nitrogen; rRNA processing; rRNA transcription; somatic stem cell division; somatic stem cell maintenance; transcription, DNA-dependent
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 Research Articles on Cdkn2a    1. Increased gene dosage of Ink4a, Arf1 and p53 delays age-associated central nervous system functional decline.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Cdkn2a antibodyPathways associated with anti-Cdkn2a antibody
 Reference Product  PubMed Publications
 Trp53 antibody  >2031 publications with Cdkn2a and Trp53
 Cdk4 antibody  >715 publications with Cdkn2a and Cdk4
 Myc antibody  >436 publications with Cdkn2a and Myc
 Mdm2 antibody  >334 publications with Cdkn2a and Mdm2
 Rassf1 antibody  >215 publications with Cdkn2a and Rassf1
 Bmi1 antibody  >120 publications with Cdkn2a and Bmi1
 Bcl2 antibody  >85 publications with Cdkn2a and Bcl2
 Pdgfrb antibody  >21 publications with Cdkn2a and Pdgfrb
 Mdm4 antibody  >15 publications with Cdkn2a and Mdm4
 Hras1 antibody  >1 publications with Cdkn2a and Hras1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram
Diseases associated with anti-Cdkn2a antibodyOrgans/Tissues associated with anti-Cdkn2a antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1389 publications with Cdkn2a and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >1319 publications with Cdkn2a and Carcinoma, Squamous Cell
 Urogenital Neoplasms Antibodies  >1317 publications with Cdkn2a and Urogenital Neoplasms
 Melanoma Antibodies  >1077 publications with Cdkn2a and Melanoma
 Lymphoma Antibodies  >755 publications with Cdkn2a and Lymphoma
 Lung Neoplasms Antibodies  >710 publications with Cdkn2a and Lung Neoplasms
 Glioma Antibodies  >533 publications with Cdkn2a and Glioma
 Pancreatic Neoplasms Antibodies  >499 publications with Cdkn2a and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >476 publications with Cdkn2a and Breast Neoplasms
 Brain Neoplasms Antibodies  >462 publications with Cdkn2a and Brain Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >869 publications with Cdkn2a and Lung
 Mixed Antibodies  >108 publications with Cdkn2a and Mixed
 Embryonic Tissue Antibodies  >102 publications with Cdkn2a and Embryonic Tissue
 Connective Tissue Antibodies  >66 publications with Cdkn2a and Connective Tissue
 Joint Antibodies  >66 publications with Cdkn2a and Joint
 Mammary Gland Antibodies  >54 publications with Cdkn2a and Mammary Gland
 Spleen Antibodies  >39 publications with Cdkn2a and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with Cdkn2a and Uncharacterized Tissue
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