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anti-P2RY1 antibody :: Rabbit P2RY1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9414776
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P2RY1, Polyclonal Antibody

★Popular Item★
 Also Known As   

P2RY1 Antibody

 Product Synonym Names    P2Y1
 Product Gene Name   

anti-P2RY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601167
 3D Structure    ModBase 3D Structure for P47900
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous levels of total P2RY1 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    2.8 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to a region derived from internal residues of human purinergic receptor P2Y, G-protein coupled, 1
 Target Name    P2RY1
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-P2RY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-P2RY1 antibody

   The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
 Product Categories/Family for anti-P2RY1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-P2RY1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-P2RY1 antibody    Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
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 Testing Data of anti-P2RY1 antibody    Gel: 10%SDS-PAGE Lysates (from left to right): A549 cell and mouse liver tissue Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
anti-P2RY1 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-P2RY1 antibody    Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/40.
anti-P2RY1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for P2RY1. It may not necessarily be applicable to this product.
 NCBI GI #    4505557
 NCBI GeneID    5028
 NCBI Accession #    NP_002554.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002563.3 [Other Products]
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 UniProt Primary Accession #    P47900 [Other Products]
 UniProt Related Accession #    P47900 [Other Products]
 Molecular Weight    42kD
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 NCBI Official Full Name    P2Y purinoceptor 1
 NCBI Official Synonym Full Names    purinergic receptor P2Y, G-protein coupled, 1
 NCBI Official Symbol    P2RY1 [Similar Products]
 NCBI Official Synonym Symbols   
P2Y1
[Similar Products]
 NCBI Protein Information    P2Y purinoceptor 1
 UniProt Protein Name    P2Y purinoceptor 1
 UniProt Synonym Protein Names   
ATP receptor; Purinergic receptor
 Protein Family    P2Y purinoceptor
 UniProt Gene Name    P2RY1 [Similar Products]
 UniProt Synonym Gene Names    P2Y1 [Similar Products]
 UniProt Entry Name    P2RY1_HUMAN
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 NCBI Summary for P2RY1    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for P2RY1    P2RY1: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: postsynaptic membrane; cell surface; mitochondrion; integral to plasma membrane; basolateral plasma membrane; dendrite; apical plasma membrane; plasma membrane

Molecular Function: ATP-activated nucleotide receptor activity; protein binding; purinergic nucleotide receptor activity, G-protein coupled; protein heterodimerization activity; receptor activity; A1 adenosine receptor binding; ADP binding; ATP binding; ADP-activated nucleotide receptor activity

Biological Process: platelet activation; regulation of vasodilation; eating behavior; positive regulation of hormone secretion; positive regulation of inositol trisphosphate biosynthetic process; sensory perception of pain; negative regulation of binding; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; response to mechanical stimulus; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of ion transport; positive regulation of protein amino acid phosphorylation; regulation of receptor activity; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; aging
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 Research Articles on P2RY1    1. Data indicate that ATP-evoked Hoechst 33258 uptake was dependent on activation of P2Y receptors P2Y1 and P2Y2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-P2RY1 antibodyPathways associated with anti-P2RY1 antibody
 Reference Product  PubMed Publications
 ADORA1 antibody  >11 publications with P2RY1 and ADORA1
 TBXA2R antibody  >2 publications with P2RY1 and TBXA2R
 P2RX1 antibody  >1 publications with P2RY1 and P2RX1
 GRM5 antibody  >1 publications with P2RY1 and GRM5
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-P2RY1 antibodyOrgans/Tissues associated with anti-P2RY1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >36 publications with P2RY1 and Cardiovascular Diseases
 Thrombosis Antibodies  >35 publications with P2RY1 and Thrombosis
 Kidney Diseases Antibodies  >17 publications with P2RY1 and Kidney Diseases
 Inflammation Antibodies  >15 publications with P2RY1 and Inflammation
 Disease Models, Animal Antibodies  >13 publications with P2RY1 and Disease Models, Animal
 Atherosclerosis Antibodies  >8 publications with P2RY1 and Atherosclerosis
 Fibrosis Antibodies  >7 publications with P2RY1 and Fibrosis
 Necrosis Antibodies  >4 publications with P2RY1 and Necrosis
 Lung Diseases Antibodies  >3 publications with P2RY1 and Lung Diseases
 Carcinoma Antibodies  >2 publications with P2RY1 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >86 publications with P2RY1 and Brain
 Vascular Antibodies  >61 publications with P2RY1 and Vascular
 Intestine Antibodies  >21 publications with P2RY1 and Intestine
 Embryonic Tissue Antibodies  >14 publications with P2RY1 and Embryonic Tissue
 Liver Antibodies  >13 publications with P2RY1 and Liver
 Mouth Antibodies  >9 publications with P2RY1 and Mouth
 Lung Antibodies  >7 publications with P2RY1 and Lung
 Placenta Antibodies  >6 publications with P2RY1 and Placenta
 Prostate Antibodies  >3 publications with P2RY1 and Prostate
 Uncharacterized Tissue Antibodies  >1 publications with P2RY1 and Uncharacterized Tissue
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