NP_002549.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
P2X purinoceptor 1
NCBI Official Synonym Full Names
purinergic receptor P2X, ligand-gated ion channel, 1
NCBI Official Synonym Symbols
NCBI Protein Information
P2X purinoceptor 1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1; purinergic receptor P2X1
UniProt Protein Name
P2X purinoceptor 1
UniProt Synonym Protein Names
ATP receptor; Purinergic receptor
UniProt Synonym Gene Names
UniProt Entry Name
P2RX1_HUMAN
NCBI Summary for P2RX1
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
UniProt Comments for P2RX1
P2X1: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: postsynaptic membrane; neuron projection; protein complex; integral to plasma membrane; plasma membrane; integral to nuclear inner membrane; lipid raft
Molecular Function: zinc ion binding; calcium channel activity; drug binding; cation channel activity; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity
Biological Process: caspase activation; synaptic transmission, glutamatergic; vasoconstriction; platelet activation; protein heterooligomerization; insemination; generation of action potential; regulation of calcium ion transport; signal transduction; response to ATP; serotonin secretion by platelet; transport; regulation of blood pressure; regulation of vascular smooth muscle contraction; ceramide biosynthetic process; ion transport; positive regulation of ion transport; blood coagulation; protein homooligomerization; cation transport
Disease: Bleeding Disorder, Platelet-type, 8
Research Articles on P2RX1
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Products associated with anti-P2RX1 antibody
Pathways associated with anti-P2RX1 antibody
Organs/Tissues associated with anti-P2RX1 antibody
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